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5 rezultatov
[Leurosine, the 3d alkaloid from Vinca rosea, in the treatmen t of Hodgkin's disease, acute lymphoblastic leukemia and lymphoblastosarcoma].
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Prijava / prijava
Leurosine sulfate (NSC-90636) in treatment of Hodgkin's disease, acute lymphoblastic leukemia, and lymphoblastic lymphosarcoma.
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Prijava / prijava
Catharanthus alkaloids, XXXVIII. Confirming structural evidence and antineoplastic activity of the bisindole alkaloids leurosine-N'b-oxide (pleurosine), roseadine and vindolicine from Catharanthus roseus.
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Prijava / prijava
Additional and confirming chemical and spectroscopic evidence for vindolicine (4), roseadine (5), and leurosine-N'b-oxide (6) is presented. Leurosine-N'b-oxide (6) was found to be exceptionally active in the B-16 melanoma test system in vivo. Roseadine (5), a new isolate of Catharanthus roseus, and
Synthesis of vinca alkaloids and related compounds, Part XCVI. Nitration study of vinblastine-type bisindole alkaloids.
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Prijava / prijava
The bisindole alkaloids vinblastine, vincristine, and N-formyl-leurosine were nitrated and subsequently converted to amino derivatives. In the case of compounds 5e and 5b cytotoxic activity has been found for non-small cell lung cancer and breast cancer in the concentration range tested
The mode of action of Vinca alkaloids.
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Prijava / prijava
P388 leukemia-bearing mice were given a single i.p. injection of [14C]-vincristine and the levels of radioactivity in the tumors and host tissues were determined as a function of time. The highest levels of radioactivity were found in the gallbladder followed by the tumor, spleen and liver,
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