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4 rezultatov
Drug sensitivity studies on clonal cell lines isolated from heteroploid tumour cell populations. I. Dose response of clones growing in monolayer cultures.
Samo registrirani uporabniki lahko prevajajo članke
Prijava / prijava
Drug sensitivity of a heteroploid tumour cell line and three clones isolated from it was studied in tissue culture. Cells of the parent line P0, and of clone P1 were fibroblast-like and pseudo- and hypodiploid. Cones P3 and P4 consisted mostly of epithelial and round cells, respectively, and were
Synthesis of vinca alkaloids and related compounds, Part XCVI. Nitration study of vinblastine-type bisindole alkaloids.
Samo registrirani uporabniki lahko prevajajo članke
Prijava / prijava
The bisindole alkaloids vinblastine, vincristine, and N-formyl-leurosine were nitrated and subsequently converted to amino derivatives. In the case of compounds 5e and 5b cytotoxic activity has been found for non-small cell lung cancer and breast cancer in the concentration range tested
The mode of action of Vinca alkaloids.
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Prijava / prijava
P388 leukemia-bearing mice were given a single i.p. injection of [14C]-vincristine and the levels of radioactivity in the tumors and host tissues were determined as a function of time. The highest levels of radioactivity were found in the gallbladder followed by the tumor, spleen and liver,
[New antitumor derivatives of vinblastine].
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Prijava / prijava
The alkaloids of Catharanthus roseus vincristine 1 and vinblastine 2 are widely used in the chemotherapy of cancer. Their nitro-derivatives have also antitumour activity [2]. The dinitro-derivatives 4, 6-9 were prepared for pharmacological investigation. Some new hydroxymethyl derivatives 12-14,
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