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4 rezultatov
Anti-inflammatory and neuroprotective effects of magnolol in chemical hypoxia in rat cultured cortical cells in hypoglycemic media.
Samo registrirani uporabniki lahko prevajajo članke
Prijava / prijava
Our previous studies demonstrated that magnolol protects neurons against chemical hypoxia by KCN in cortical neuron-astrocyte mixed cultures (14). In the present study, we examined whether the neuroprotective effect of magnolol involve modulating inflammatory mediators, prostaglandin E2 (PGE2) and
Magnolol protects cortical neuronal cells from chemical hypoxia in rats.
Samo registrirani uporabniki lahko prevajajo članke
Prijava / prijava
The protective effect of magnolol, a component of Magnolia officinalis, against hypoxia-induced cell injury in cortical neuron-astrocyte mixed cultures was examined. Exposure of the cells to chemical hypoxia (0.5 mM KCN) produced morphological changes in neurons but not in astrocytes. KCN induced
Magnolol suppresses hypoxia-induced angiogenesis via inhibition of HIF-1α/VEGF signaling pathway in human bladder cancer cells.
Samo registrirani uporabniki lahko prevajajo članke
Prijava / prijava
The hypoxic environment in tumors is an important factor causing tumor angiogenesis by activating the key transcription factor, hypoxia-inducible factors-1α (HIF-1α). Magnolol isolated from Magnolia officinalis has been reported to exhibit an anticancer activity via elevation of apoptosis. However,
Anti-angiogenic and anti-inflammatory effect of Magnolol in the oxygen-induced retinopathy model.
Samo registrirani uporabniki lahko prevajajo članke
Prijava / prijava
OBJECTIVE
In the present study, we investigated the effects of Magnolol on the retinal neovascularization (RNV) and local glial cells in an oxygen-induced retinopathy (OIR) model and explored their molecular mechanisms.
METHODS
Neonatal C57BL/6J mice were subjected to 75% O2 ± 5% from postnatal day
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