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maytansine/rak dojke
Povezava se shrani v odložišče
Stran 1 iz 47 rezultatov
Minimal single-agent activity of maytansine in refractory breast cancer: a Southwest Oncology Group study.
Samo registrirani uporabniki lahko prevajajo članke
Prijava / prijava
Maytansine is an experimental antitumor agent that has shown minimal efficacy against breast cancer with minimal myelosuppression in phase I trials. Forty-one patients with advanced drug-resistant breast cancer were treated with a 5-day intermittent iv infusion of maytansine repeated every 21 days.
Phase II study of maytansine in advanced breast cancer.
Samo registrirani uporabniki lahko prevajajo članke
Prijava / prijava
T-DM1 in the Neo-Adjuvant Treatment of HER2-Positive Breast Cancer: Impact of the KRISTINE (TRIO-021) Trial.
Samo registrirani uporabniki lahko prevajajo članke
Prijava / prijava
Neo-adjuvant chemotherapy (NAC) can facilitate breast conservation, allows in vivo testing of chemotherapy sensitivity and provides a route to accelerated approval of new therapies. For HER2 positive breast cancer, the anti-HER2 monoclonal antibody, trastuzumab, is a standard component of
Trastuzumab Emtansine: A Review of Its Adjuvant Use in Residual Invasive HER2-Positive Early Breast Cancer
Samo registrirani uporabniki lahko prevajajo članke
Prijava / prijava
Trastuzumab emtansine (Kadcyla®), an antibody-drug conjugate of trastuzumab (Herceptin®) connected by a thioether linker to the microtubule inhibitor DM1 (a cytotoxic derivative of maytansine), provides direct intracellular delivery of the potent cytotoxin DM1 to
Trastuzumab emtansine in advanced human epidermal growth factor receptor 2-positive breast cancer.
Samo registrirani uporabniki lahko prevajajo članke
Prijava / prijava
BACKGROUND
Ado- trastuzumab emtansine (T-DM1) is a human epidermal growth factor receptor 2 (HER2)-targeted antibody-drug conjugate composed of trastuzumab, a stable linker (MCC), and the cytotoxic agent DM1 (derivative of maytansine; mertansine). T-DM1 retains the mechanisms of action of
Novel approaches to target HER2-positive breast cancer: trastuzumab emtansine.
Samo registrirani uporabniki lahko prevajajo članke
Prijava / prijava
The human epidermal growth factor receptor 2 (HER2) is overexpressed in 20% of breast carcinomas. Prior to the development of targeted therapies, HER2-positive breast cancer was associated with more aggressive disease and poor prognosis. Trastuzumab emtansine (T-DM1) is an antibody-drug conjugate
From Natural Products to Designer Drugs: Development and Molecular Mechanisms Action of Novel Anti-Microtubule Breast Cancer Therapeutics.
Samo registrirani uporabniki lahko prevajajo članke
Prijava / prijava
Microtubule-targeted drugs (MTDs) have been on the forefront of breast cancer chemotherapy. Classic MTDs, such as paclitaxel and their semisynthetic derivatives, have achieved considerable success in the clinical management of breast neoplasms. In order to improve the specificity and to reduce
Trastuzumab emtansine in breast cancer.
Samo registrirani uporabniki lahko prevajajo članke
Prijava / prijava
BACKGROUND
Trastuzumab emtansine (T-DM1) is a human epidermal growth factor receptor 2 (HER2)-targeted antibody-drug conjugate (ADC) composed of trastuzumab, a stable linker (MCC), and the cytotoxic agent DM1 (derivative of maytansine). Administration of T-DM1 leads to limited systemic exposure of
Trastuzumab emtansine: a novel antibody-drug conjugate for HER2-positive breast cancer.
Samo registrirani uporabniki lahko prevajajo članke
Prijava / prijava
BACKGROUND
Trastuzumab emtansine (T-DM1) is an antibody-drug conjugate (ADC) that combines intracellular delivery of the potent cytotoxic agent, DM1 (a derivative of maytansine) with the antitumor activity of trastuzumab. While there are several ADCs in Phase III development, T-DM1 is the only one
The potential for trastuzumab emtansine in human epidermal growth factor receptor 2 positive metastatic breast cancer: latest evidence and ongoing studies.
Samo registrirani uporabniki lahko prevajajo članke
Prijava / prijava
The treatment of breast cancer that is driven by amplification and overexpression of human epidermal growth factor receptor 2 (HER2) has been drastically improved by the development of HER2-targeted therapies including trastuzumab and lapatinib. While outcomes for patients diagnosed with
Maytansine: a phase I study of an ansa macrolide with antitumor activity.
Samo registrirani uporabniki lahko prevajajo članke
Prijava / prijava
Maytansine has significant antitumor activity in animal model systems. The initial clinical trial of maytansine was carried out in 38 adult solid tumor patients. Five daily bolus injections were repeated at 21-day intervals. A total of 78 courses were administered over a dose range of 0.1--0.8
Current and emerging targeted therapies for metastatic breast cancer.
Samo registrirani uporabniki lahko prevajajo članke
Prijava / prijava
The success of endocrine therapies for hormone receptor-positive breast cancer and trastuzumab and lapatinib for targeting human epidermal growth factor receptor 2 (HER2)-positive tumors has paved the way for the clinical development of several other metastatic breast cancer (MBC)-targeted
Adverse Events of Trastuzumab Emtansine (T-DM1) in the Treatment of HER2-Positive Breast Cancer Patients.
Samo registrirani uporabniki lahko prevajajo članke
Prijava / prijava
The human epidermal growth factor receptor 2 (HER2) is commonly associated with poor prognosis and is overexpressed in approximately 15-20% of all breast cancers. The introduction of HER2-targeted therapies led to significant improvement in the prognosis of patients with HER2-positive breast cancer,
Maytansine-loaded star-shaped folate-core PLA-TPGS nanoparticles enhancing anticancer activity.
Samo registrirani uporabniki lahko prevajajo članke
Prijava / prijava
The efficient delivery of therapeutic molecule agents into target cells of interest is a critical challenge to broad application of non-viral vector systems. In this research, maytansine-loaded star-shaped folate-core polylactide-D-α-tocopheryl polyethylene glycol 1000 succinate (FA-PLA-TPGS) block
Preclinical Activity of the Novel Anti-Prolactin Receptor (PRLR) Antibody-Drug Conjugate REGN2878-DM1 in PRLR-Positive Breast Cancers.
Samo registrirani uporabniki lahko prevajajo članke
Prijava / prijava
The Prolactin Receptor (PRLR) is a type 1 cytokine receptor that is expressed in a subset of breast cancers and may contribute to its pathogenesis. It is relatively overexpressed in approximately 25% of human breast tumors while expressed at low levels in some normal human tissues including the
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