methoxsalen/nekroza

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Protective Effects of Methoxsalen Supplementation on Chronic Alcohol-Induced Osteopenia and Steatosis in Rats.

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Prijava / prijava

Osteopenia or osteoporosis occurs frequently in alcoholics and patients with alcoholic fatty liver disease. Methoxsalen (MTS), 8-methoxypsoralen, improved osteoporosis in ovariectomized and diabetic mouse models; however, its effects on alcohol-induced osteopenia and steatosis have not been

Human halothane metabolism, lipid peroxidation, and cytochromes P(450)2A6 and P(450)3A4.

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Prijava / prijava

OBJECTIVE Halothane undergoes both oxidative and reductive metabolism by cytochrome P450 (CYP), respectively causing rare immune-mediated hepatic necrosis and common, mild subclinical hepatic toxicity. Halothane also causes lipid peroxidation in rodents in vitro and in vivo, but in vivo effects in

Low-fluence carbon dioxide laser irradiation of lentigines.

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Prijava / prijava

Low-fluence carbon dioxide (CO2) laser irradiation of skin has previously been shown to induce damage limited primarily to the epidermis. To evaluate whether this technique was therapeutically effective for pigmented epidermal lesions, ten lentigines caused by methoxsalen and ultraviolet light

Styrene-induced hepatotoxicity in mice depleted of glutathione.

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Prijava / prijava

In mice depleted of glutathione (GSH) by pretreatment with an inhibitor of GSH synthesis, buthionine sulfoximine (BSO; 1 hr before styrene, 2 mmol/kg or higher doses, ip), styrene (0.96-5.76 mmol/kg, po) produced hepatotoxicity characterized by an increase in serum alanine transaminase activity and

Metabolism-dependent hepatotoxicity of methimazole in mice depleted of glutathione.

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Prijava / prijava

Methimazole (MMI) (>0.1 mmol kg(-1), p.o.) given in combination with DL-buthionine sulphoximine (BSO) (3 mmol kg(-1), i.p., 1 h before MMI administration), an inhibitor of glutathione (GSH) synthesis, caused liver injury in mice. The injury was characterized by centrilobular necrosis of hepatocytes

Nephrotoxicity of thiabendazole in mice depleted of glutathione by treatment with DL-buthionine sulphoximine.

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Prijava / prijava

Thiabendazole [2-(4'-thiazolyl)benzimidazole; TBZ] is widely used as an anthelmintic and a fungicide. TBZ (50-400 mg/kg body weight administered by oral intubation) produced nephrotoxicity in male ICR mice pretreated with an inhibitor of glutathione synthesis, DL-buthionine sulphoximine (BSO; 4

Hepatotoxicity of eugenol in mice depleted of glutathione by treatment with DL-buthionine sulfoximine.

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Prijava / prijava

Eugenol is widely used as a food flavoring agent and a dental analgesic. Mice treated with eugenol (400-600 mg/kg, po) in combination with an inhibitor of glutathione (GSH) synthesis, buthionine sulfoximine (BSO; 1 hr before eugenol, 4 mmol/kg, ip) developed hepatotoxicity characterized by increases

Extracorporeal photopheresis (ECP) in patients with steroid-dependent Crohn's disease: an open-label, multicenter, prospective trial.

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Prijava / prijava

BACKGROUND Extracorporeal photopheresis (ECP) involves ex vivo leukocyte treatment with methoxsalen and UVA light to generate a tolerogenic response. A previous trial demonstrated that ECP permits corticosteroid withdrawal in steroid-dependent Crohn's disease (CD) patients who were in clinical

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