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[Biochemical and clinical aspects of melatonin biosynthesis induced by noradrenalin in experiment].

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Prijava / prijava

Melatonin has been considered as a hormone with potent immunomodulating, anxiolitic and antioxidative properties. Melatonin is also known to be inhibitor of sympatoadrenal activity. The study was aimed to elucidate changes in melatonin synthesis induced by noradrenalin IM injection. Melatonin plasma

Locus Coeruleus atrophy doesn't relate to fatigue in Parkinson's disease.

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Prijava / prijava

Fatigue is a frequent complaint among healthy population and one of the earliest and most debilitating symptoms in Parkinson's disease (PD). Earlier studies have examined the role of dopamine and serotonin in pathogenesis of fatigue, but the plausible role of noradrenalin (NA) remains underexplored.

Early locus coeruleus degeneration and olfactory dysfunctions in Tg2576 mice.

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Prijava / prijava

Olfactory deficiency has been reported in the early stages of Alzheimer's disease (AD) in humans but is very poorly understood due to the lack of investigations in animal models of AD. Recent studies point to the noradrenergic system as an important target of the AD pathological process. In

Headaches and sinus disease: the endoscopic approach.

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Prijava / prijava

Headaches can be of sinugenic origin even if this cause may not be suspected from the case history. Endoscopy of the lateral nasal wall with rigid cold light endoscopes in combination with polytomography or computed tomography usually will reveal the underlying causes hidden from the unaided eye,

[Pain management in palliative care. Current aspects of medicinal therapy].

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Prijava / prijava

Palliative care patients do not only suffer from cancer pain but also from painful muscle spasticity due to multiple sclerosis, amyotrophic lateral sclerosis, after stroke or due to dementia if damage of the pyramidal motor system is present. Centrally active muscle relaxants can be helpful also

The role of blood pressure in lacunar strokes preceded by TIAs.

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Prijava / prijava

Lacunar strokes (LS) are often preceded by repetitive transitory ischaemic attacks (TIAs) known as 'capsular warning syndrome'. The treatment of these symptoms remains controversial. Anticoagulants are often used in this situation, most of the time, however, with no or little benefit. Since it is

Case report: profound hypotension associated with labetalol therapy in a patient with cerebral aneurysms and subarachnoid hemorrhage.

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Prijava / prijava

OBJECTIVE Labetalol is an effective antihypertensive medication frequently used to treat systemic hypertension in acute care settings, including the management of hypertension associated with a subarachnoid hemorrhage. We present a case of profound hypotension, refractory to inotropic and

Striatal pathology underlies prion infection-mediated hyperactivity in mice.

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Prijava / prijava

Although prion diseases are most commonly modeled using the laboratory mouse, the diversity of prion strains, behavioral testing and neuropathological assessments hamper our collective understanding of mouse models of prion disease. Here we compared several commonly used murine strains of prions in

Rett Syndrome -- an update.

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Prijava / prijava

Rett syndrome is a progressive, usually sporadic and rarely familial, disabling neurodevelopmental disorder with onset in early childhood presenting clinically with mental retardation, behavioral changes, late movement disturbances, loss of speech and hand skills, ataxia, apraxia, irregular

Forced swimming stress does not affect monoamine levels and neurodegeneration in rats.

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Prijava / prijava

OBJECTIVE The current study was aimed to investigate the correlations between immobility time in the forced swimming test (FST, a behavioral indicator of stress level) and hippocampal monoamine levels (markers of depression), plasma adrenalin level (a peripheral marker of stress) as well as

Multiple roles of tissue plasminogen activator in schizophrenia pathophysiology.

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Prijava / prijava

Schizophrenia, a disabling mental disorder, is characterized by brain atrophy, especially in the superior temporal gyrus and the medial temporal lobe, which includes the hippocampus and the amygdala. The model that better explains brain atrophy includes a trigger and a predisposing condition. The

[Brain-derived neurotrophic factor (BDNF) and mood disorder].

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Prijava / prijava

Brain-derived neurotrophic factor (BDNF) is the most abundant and widely expressed neurotrophin in the brain. BDNF is believed to play an important role in depressive disorder. Chronic stress decreases the synthesis of hippocampal BDNF, which leads to atrophy of the hippocampus in the depressed

Charles Bonnet Syndrome: successful treatment of visual hallucinations due to vision loss with selective serotonin reuptake inhibitors.

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Prijava / prijava

Visual hallucinations are a common and often distressing consequence of vision loss, particularly in age-related macular degeneration. Charles Bonnet Syndrome (CBS) is defined by the triad of complex visual hallucinations, ocular pathology causing visual deterioration and preserved cognitive status.

The effect of 6-hydroxydopamine on the rabbit cochlea.

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Prijava / prijava

6-OH-DA is an isomer of noradrenalin which is selectively taken up by adrenergic axons. Noradrenalin stores are displaced by 6-OH-DA and at a certain intraneuronal concentration, degeneration of the terminals occurs and results in a chemical sympathectomy. The effects of 6-OH-DA on the rabbit

'A single night' beneficial effects of adaptive servo-ventilation on cardiac overload, sympathetic nervous activity, and myocardial damage in patients with chronic heart failure and sleep-disordered breathing.

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Prijava / prijava

BACKGROUND Sleep-disordered breathing (SDB), including Cheyne-Stokes respiration with central sleep apnea (CSR-CSA), causes a deterioration in the prognosis of patients with chronic heart failure (CHF). Adaptive servo-ventilation (ASV) and oxygen therapy (O(2)) are useful for improving the CSR-CSA

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