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nothapodytes foetida/rak
Povezava se shrani v odložišče
Stran 1 iz 19 rezultatov
Comparison of techniques for the extraction of the anti-cancer drug camptothecin from Nothapodytes foetida.
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Prijava / prijava
Extraction methods using stirring extraction, Soxhlet extraction, ultrasonic extraction and microwave-assisted extraction (MAE) were evaluated for the percentage extraction of camptothecin (CPT) and 9-methoxycamptothecin (9-Me-CPT) from Nothapodytes foetida. The extracts were analyzed by high
Camptothecinoids from the seeds of Taiwanese Nothapodytes foetida.
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Prijava / prijava
Two new alkaloids, 9-methoxy-18,19-dehydrocamptothecin (1) and 5- hydroxymappicine-20-O-beta-glucopyranoside (2a/2b as a racemic mixture), together with nine known compounds: camptothecin (3), 9-methoxy-camptothecin (4), 5-hydroxycamptothecin (5a/5b racemic mixture), 5-hydroxy-9-methoxycamptothecin
An endophytic fungus from Nothapodytes foetida that produces camptothecin.
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Prijava / prijava
A fungal endophytic isolate, camptothecin, has been isolated from the inner bark of the plant Nothapodytes foetidafrom the Western coast of India. The fungus, which belongs to the family Phycomycetes, produced the anticancer drug lead compound camptothecin (1) when grown in a synthetic liquid medium
Camptothecin distribution and content in Nothapodytes nimmoniana.
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Prijava / prijava
Nothapodytes nimmoniana is an important anti-cancer medicinal plant which possesses various bioactive substances, of which camptothecin (CPT) is the most important. CPT is mainly obtained by extraction from plants. However, extraction is problematic because of the lack of reference information,
9-methoxycamptothecin from Nothapodytes foetida induces apoptosis in murine sarcoma S180 cells.
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Prijava / prijava
9-Methoxycamptothecin (MCPT) was found to have antitumour activities through topoisomerase inhibition. However, the type of cell death induced in the tumour cells treated with MCPT was not elucidated. In this study, MCPT and camptothecin were isolated from Nothapodytes foetida distributed in Hubei
New and highly efficient column chromatographic extraction and simple purification of camptothecin from Camptotheca acuminata and Nothapodytes pittosporoides.
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BACKGROUND
Camptothecin, a widely used natural anti-cancer drug, is difficult to extract and purify effectively from plants.
OBJECTIVE
To develop new and highly efficient extraction and purification methods for analysis and production of camptothecin from leaves and fruits of Camptotheca acuminata
Prospecting for Camptothecines from Nothapodytes nimmoniana in the Western Ghats, South India: identification of high-yielding sources of camptothecin and new families of camptothecines.
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Prijava / prijava
Camptothecin (CPT), a monoterpene alkaloid, is an important anti-cancer compound obtained from several plant sources including Camptotheca acuminta (from China) and Nothapodytes nimmoniana (from India). Currently, by far the highest levels of CPT (approximately 0.3% w/w) are reported from
Determination of camptothecins in DMSO extracts of Nothapodytes foetida by direct injection capillary electrophoresis.
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Prijava / prijava
A rapid capillary electrophoresis procedure was developed for determining the anti-cancer components, camptothecins, in Nothapodytes foetida. The hydrophobic compound was extracted from plant tissue (ca. 1 mL of DMSO for 100 mg of dried plant tissue) with a water-miscible organic solvent, DMSO, at
Transcriptome-wide identification, characterization and phylogenomic analysis of cytochrome P450s from Nothapodytes nimmoniana reveal candidate genes involved in camptothecin biosynthetic pathway
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Prijava / prijava
The plant Nothapodytes nimmoniana is a source of important anticancer compound camptothecin (CPT) which is being used in the treatment of colorectal, lung and ovarian cancers. Camptothecin is biosynthesized by the combination of seco-iridoid and indole pathway in plants. Majority of the biosynthetic
Comparative studies on the camptothecin content from Nothapodytes foetida and Ophiorrhiza species.
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Camptothecin is an anticancer quinoline alkaloid effective against colon cancer. It acts by inhibition of the enzyme DNA topoisomerase I. A comparative study of camptothecin from the indigenous plants namely Nothapodytes foetida, Ophiorrhiza mungos and Ophiorrhiza rugosa indicated highest yields of
Direct analysis of camptothecin from Nothapodytes nimmoniana by desorption electrospray ionization mass spectrometry (DESI-MS).
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Prijava / prijava
Desorption electrospray ionization was employed for fast and direct ambient detection of the anti-tumor drug, camptothecin, and its derivative, 9-methoxycamptothecin in Nothapodytes nimmoniana. Different parts of the plant such as leaves, stems and bark were examined. The ion intensities suggest
Development of polymorphic microsatellite loci in Nothapodytes nimmoniana, a medicinally important tree from the Western Ghats, India.
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Prijava / prijava
Nothapodytes nimmoniana is a medicinally important tree species that occur in the Western Ghats, a megadiversity hotspot in southern India. Inner stem bark of the tree contains an important anti-cancer alkaloid, camptothecin for which the natural population of the tree is heavily harvested. In this
Transcriptome analysis of stem wood of Nothapodytes nimmoniana (Graham) Mabb. identifies genes associated with biosynthesis of camptothecin, an anti-carcinogenic molecule.
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Prijava / prijava
Camptothecin (CPT), a monoterpene indole alkaloid, is a potent inhibitor of DNA topoisomerase I and has applications in treating ovarian, small lung and refractory ovarian cancers. Stem wood tissue of Nothapodytes nimmoniana (Graham) Mabb. (family Icacinaceae) is one of the richest sources of CPT.
Sequestration of camptothecin, an anticancer alkaloid, by chrysomelid beetles.
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Prijava / prijava
Camptothecin (CPT), a monoterpene indole alkaloid, is a potent inhibitor of eukaryotic toposiomerase-I. Several derivatives of CPT are in clinical use against ovarian and lung cancers. CPT has been reported from several plant species belonging to the order Asterids, with the highest concentration in
Effect of precursors feeding and media manipulation on production of novel anticancer pro-drug camptothecin from endophytic fungus.
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Prijava / prijava
We have established methodology for the isolation and characterization of a novel endophytic fungus from the inner bark of medicinal plant Nothapodytes foetida, which produced camptothecin in Sabouraud broth (SB) under shake flask conditions. Camptothecin and its related compounds are at present
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