oligospermia/tyrosine

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Severe oligozoospermia in a young man with chronic myeloid leukemia on long-term treatment with imatinib started before puberty.

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Prijava / prijava

OBJECTIVE To report the effect of long-term treatment with the tyrosine kinase inhibitor imatinib started before the onset of puberty on semen parameters, bone mineral density, and hormone values. METHODS Case report. METHODS University hospital. METHODS An 18-year-old man given treatment with

Overexpression of epidermal growth factor induced hypospermatogenesis in transgenic mice.

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Prijava / prijava

The in vivo role of epidermal growth factor (EGF) is not well defined even though its effects on culture cells were well studied. To understand the developmental, physiological, and pathological roles of EGF, we have generated transgenic mice widely expressing human EGF with the use of the

Metabolomics analysis of seminal plasma in patients with idiopathic Oligoasthenoteratozoospermia using high-resolution NMR spectroscopy.

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Prijava / prijava

Male infertility is a global health issue caused by a combination of different factors. Specialists generally rely on semen analysis to diagnose male infertility. However, it is known that diagnostic semen analysis fails to identify about 50% of male infertility disorders. Recently,

Expression of epidermal growth factor in transgenic mice causes growth retardation.

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Prijava / prijava

The epidermal growth factor (EGF) family of peptides signals through the erbB family of receptor tyrosine kinases and plays important roles in development and tumorigenesis. Both EGF and transforming growth factor (TGF)-alpha only bind to erbB1 and activate it. The precursor of EGF is distinct from

Isoprenoid pathway dysfunction in human male infertility.

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Prijava / prijava

The isoprenoid pathway produces 3 key metabolites: digoxin (membrane sodium-potassium ATPase inhibitor and regulator of neurotransmitter transport), dolichol (regulates N-glycosylation of proteins), and ubiquinone (free radical scavenger). The pathway was assessed in patients with human male

[Correlation of single nucleotide polymorphisms rs995030 and rs4474514 of the KITLG gene with male infertility].

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Prijava / prijava

To investigate the correlation of the single nucleotide polymorphisms rs995030 and rs4474514 of the tyrosine kinase receptor-specific ligand (KITLG) gene with the risk of male infertility.This study included 360 patients with idiopathic male infertility and

Dynamics, ultrastructure and gene expression of human in vitro organized testis cells from testicular sperm extraction biopsies.

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Prijava / prijava

Is it possible to induce in vitro reorganization of primary human testis cells from testicular sperm extraction (TESE) biopsies, maintain their long-term cultivation in a 2D system and identify cellular compositions? In vitro reorganization of primary human testis cells from TESE biopsies and their

Identification of biochemical differences between different forms of male infertility by nuclear magnetic resonance (NMR) spectroscopy.

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Prijava / prijava

OBJECTIVE The aim of this study was to analyze the seminal plasma of patients with idiopathic/male factor infertility and healthy controls with proven fertility by NMR spectroscopy, with a hope of establishing difference in biomarker profiles, if any, between the groups. METHODS A total of 103

Association of genetic markers within the KIT and KITLG genes with human male infertility.

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Prijava / prijava

BACKGROUND There is much evidence involving the KIT tyrosine kinase receptor and its ligand KITLG in the survival and proliferation of germ cells. Animal models and functional studies in humans suggest that this signalling pathway plays a role in male infertility. METHODS We studied three and two

Evidence for catecholaminergic, neuronlike cells in the adult human testis: changes associated with testicular pathologies.

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Prijava / prijava

Neuronlike, catecholaminergic cells expressing tyrosine-hydroxylase (TH) have recently been found in the testis of a nonhuman primate species, the rhesus monkey. We examined whether neuronlike cells are present in the human testis. To this end, we first determined if the genes for TH and for a

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