phenethyl isothiocyanate/camellia

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The effects of phenethyl isothiocyanate, N-acetylcysteine and green tea on tobacco smoke-induced lung tumors in strain A/J mice.

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Prijava / prijava

Male and female strain A/J mice were exposed to a mixture of cigarette sidestream and mainstream smoke at a chamber concentration of total suspended particulates of 82.5 mg/m3. Exposure time was 6 h/day, 5 days/week for 5 months. The animals were allowed to recover for another 4 months in filtered

[Natural compounds in chemoprevention of esophageal squamous cell tumors--experimental studies].

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Chemoprevention refers to prevention of tumor formation due to administration of nontoxic synthetic or natural compounds, which can block or weaken the influence of carcinogens on target cells or even reverse previously formed lesions. In esophageal squamous cell carcinoma--which belongs to the

Successful and not so successful chemoprevention of tobacco smoke-induced lung tumors.

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Strain A/J mice underwent whole body exposure for 6 hours a day, 5 days a week, for 5 months to a mixture of cigarette sidestream and mainstream smoke (89%-11%; total suspended particulates 80-150 mg/m3), then were kept for another 4 months in air before being killed for scoring of lung tumors. In 7

Modulatory properties of various natural chemopreventive agents on the activation of NF-kappaB signaling pathway.

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OBJECTIVE To study and compare effects of selected natural chemopreventive agents on the transcription activation of nuclear factor-kappa B (NF-kappaB) in human HT-29 colon cancer cells. METHODS The natural chemopreventive compounds isothiocyanates (ITCs) found in cruciferous vegetables, flavonoids

Induction of xenobiotic enzymes by the MAP kinase pathway and the antioxidant or electrophile response element (ARE/EpRE).

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Cellular responses to xenobiotic-induced stress can signal proliferation, differentiation, homeostasis, apoptosis, or necrosis. To better understand the underlying molecular mechanisms after exposure to xenobiotics or drugs, we studied the signal transduction pathways, the mitogen-activated protein

Oxidative stress and dietary phytochemicals: Role in cancer chemoprevention and treatment.

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Several epidemiological observations have shown an inverse relation between consumption of plant-based foods, rich in phytochemicals, and incidence of cancer. Phytochemicals, secondary plant metabolites, via their antioxidant property play a key role in cancer chemoprevention by suppressing

Effects of food factors on signal transduction pathways.

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Prijava / prijava

Consumption of plant-derived foods, especially fruits and vegetables, has been linked to decreased risk of cancer. Laboratory studies with animals and cells in culture have shown cancer preventive activity of chemicals isolated from soy, tea, rice and many green, yellow and orange fruits and

Candidate dietary phytochemicals modulate expression of phase II enzymes GSTP1 and NQO1 in human lung cells.

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Many phytochemicals possess cancer-preventive properties, some putatively through phase II metabolism-mediated mutagen/oxidant quenching. We applied human lung cells in vitro to investigate the effects of several candidate phytopreventive agents, including green tea extracts (GTE), broccoli sprout

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