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10 rezultatov
Systemic phlorizin prevents gold thioglucose necrosis in the ventromedial hypothalamus.
Samo registrirani uporabniki lahko prevajajo članke
Prijava / prijava
Intraventricular and intrahypothalamic infusions of phlorizin (PHL) are known to cause hyperphagia and to prevent gold thioglucose (GTG) lesion formation in the ventromedial hypothalamus (VMH), respectively. In this study, PHL, administered IP in a large dose (900 mg/kg), completely inhibited GTG
Phlorizin inhibition of hypothalamic necrosis induced by gold thioglucose.
Samo registrirani uporabniki lahko prevajajo članke
Prijava / prijava
Cardioprotective effect of ritonavir, an antiviral drug, in isoproterenol induced myocardial necrosis: a new therapeutic implication.
Samo registrirani uporabniki lahko prevajajo članke
Prijava / prijava
BACKGROUND
Ritonavir is a HIV protease inhibitor. In addition to its antiviral effect, Ritonavir directly inhibits the insulin-regulated glucose transporter GLUT4 and blocks glucose entry into fat and muscle cells. However, the effect of Ritonavir on cardiac GLUT4 inhibition during myocardial
Phlorizin Supplementation Attenuates Obesity, Inflammation, and Hyperglycemia in Diet-Induced Obese Mice Fed a High-Fat Diet.
Samo registrirani uporabniki lahko prevajajo članke
Prijava / prijava
Obesity, along with its related complications, is a serious health problem worldwide. Many studies reported the anti-diabetic effect of phlorizin, while little is known about its anti-obesity effect. We investigated the beneficial effects of phlorizin on obesity and its complications, including
Phlorizin-induced glycosuria does not prevent gentamicin nephrotoxicity in rats.
Samo registrirani uporabniki lahko prevajajo članke
Prijava / prijava
Because rats with streptozotocin-induced diabetes mellitus (DM) have a high solute diuresis (glycosuria of 10 to 12 g/day), we have suggested that this may in part be responsible for their resistance to gentamicin-induced acute renal failure (ARF). The protection from gentamicin nephrotoxicity was
Docosahexaenoic acid ester of phloridzin inhibit lipopolysaccharide-induced inflammation in THP-1 differentiated macrophages.
Samo registrirani uporabniki lahko prevajajo članke
Prijava / prijava
Phloridzin or phlorizin (PZ) is a predominant phenolic compound found in apple and also used in various natural health products. Phloridzin shows poor absorption and cellular uptake due to its hydrophilic nature. The aim was to investigate and compare the effect of docosahexaenoic acid (DHA) ester
Gold thioglucose obesity syndrome.
Samo registrirani uporabniki lahko prevajajo članke
Prijava / prijava
Parenteral administration of gold thioglucose to mice produces an area or necrosis in the ventromedial portion of the hypothalamus. The lesion, like lesions produced by electrocautery of this area, causes hyperphagia and consequent obesity. The glucose moiety of gold thioglucose is essential for
Precision-cut dog renal cortical slices in dynamic organ culture for the study of cisplatin nephrotoxicity.
Samo registrirani uporabniki lahko prevajajo članke
Prijava / prijava
The dog is the non-rodent species the most often used in preclinical drug safety evaluation. In this study, we established a new system of precision-cut dog renal cortical slices, evaluated their biochemical, functional, and morphological integrity, and determined the effects of cisplatin
Exogenous Insulin Infusion Can Decrease Atherosclerosis in Diabetic Rodents by Improving Lipids, Inflammation, and Endothelial Function.
Samo registrirani uporabniki lahko prevajajo članke
Prijava / prijava
OBJECTIVE
The objective of this study is to evaluate whether exogenously induced hyperinsulinemia may increase the development of atherosclerosis.
UNASSIGNED
Hyperinsulinemia, induced by exogenous insulin implantation in high-fat fed (60% fat HFD) apolipoprotein E-deficient mice (ApoE-/-) mice,
Markers of Islet Endothelial Dysfunction Occur in Male B6.BKS(D)-Leprdb/J Mice and May Contribute to Reduced Insulin Release.
Samo registrirani uporabniki lahko prevajajo članke
Prijava / prijava
Islet endothelial cells produce paracrine factors that support β-cell function and growth. Endothelial dysfunction underlies diabetic microvascular complications; thus, we hypothesized that in diabetes, islet endothelial cells become dysfunctional, which may contribute to β-cell secretory
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