provitamin a/levkemija

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Maternal dietary risk factors in childhood acute lymphoblastic leukemia (United States).

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OBJECTIVE Acute lymphoblastic leukemia (ALL) is the most common childhood cancer, and the second most common cause of mortality in children aged 1-14 years. Recent research has established that the disease can originate in utero, and thus maternal diet may be an important risk factor for

Inhibition of growth and induction of differentiation of promyelocytic leukemia (HL-60) by carotenoids from Crocus sativus L.

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Prijava / prijava

The effects of carotenoids of Crocus sativus L. (saffron) on cell proliferation and differentiation of HL-60 cells have been studied and compared with those of all-trans retinoic acid. Our results demonstrated that the doses inducing 50% inhibition of cell growth were 0.12 microM for all-trans

A novel cleavage product formed by autoxidation of lycopene induces apoptosis in HL-60 cells.

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Dietary carotenoids have been thought to have beneficial effects on human health through their antioxidant activity, provitamin A activity, and effects on cancer cell propagation. Recent studies suggest that oxidation products or metabolites are involved in biological activities of carotenoids. We

Oxidative conversion of carotenoids to retinoids and other products.

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Prijava / prijava

In vertebrates, provitamin A carotenoids are converted to retinal by beta-carotene-15,15'-dioxygenase. The enzyme activity is expressed specifically in intestinal epithelium and in liver. The intestinal enzyme not only plays an important role in providing animals with vitamin A, but also determines

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