pyrrol/dental caries

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Design, synthesis, and biological activity of novel 5-((arylfuran/1H-pyrrol-2-yl)methylene)-2-thioxo-3-(3-(trifluoromethyl)phenyl)thiazolidin-4-ones as HIV-1 fusion inhibitors targeting gp41.

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Prijava / prijava

On the basis of our earlier molecular docking analysis, we designed and synthesized 5-((arylfuran/1H-pyrrol-2-yl)methylene)-2-thioxo-3-(3-(trifluoromethyl)phenyl)thiazolidin-4-ones (12a-o) as HIV-1 entry inhibitors. Compounds 12a-o effectively inhibited infection by both laboratory-adapted and

Crystal structure and NMR binding reveal that two small molecule antagonists target the high affinity ephrin-binding channel of the EphA4 receptor.

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Prijava / prijava

The Eph receptor tyrosine kinases regulate a variety of physiological and pathological processes not only during development but also in adult organs, and therefore they represent a promising class of drug targets. The EphA4 receptor plays important roles in the inhibition of the regeneration of

Hemoglobin Warsaw (Phe beta 42(CD1)----Val), an unstable variant with decreased oxygen affinity. Characterization of its synthesis, functional properties, and structure.

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Prijava / prijava

In Hb Warsaw Val replaces the Phe normally present at the heme contact position beta 42 (CD1). This variant is unstable, and it readily undergoes methemoglobin formation. In DEAE-cellulose chromatography, the variant hemoglobin co-eluted with Hb A; a partially heme-depleted fraction of the variant,

[30]Hexaphyrin(2.1.2.1.2.1) as Aromatic Planar Ligand and Its Trinuclear Rhodium(I) Complex.

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Prijava / prijava

Expanded porphyrins are attractive research targets because of their large and flexible structures, optical and electrochemical properties, and diverse coordination abilities. We are interested in the use of double bonds within expanded porphyrins because double bonds could conduct isomerization,

Synthesis of a Porphyrin(2.1.2.1) Nanobelt and Its Ability To Bind Fullerene.

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Prijava / prijava

This Letter details a simple and effective method to synthesize a porphyrin(2.1.2.1)-based nanobelt NBNi₃ via condensation reactions of 1,2,4,5-tetra(pyrrol-2-yl)benzene and benzaldehydes. NBNi₃ consists of three arch-shaped porphyrins(2.1.2.1) and benzene linkages with a

Design, synthesis, in vitro and in silico evaluation of new pyrrole derivatives as monoamine oxidase inhibitors.

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Prijava / prijava

In an effort to develop potent monoamine oxidase (MAO) inhibitors, new pyrrole derivatives were obtained via the selective reduction of the CC bonds of 1-(1-methyl-1H-pyrrol-2-yl)-3-[5-(aryl)furan-2-yl]prop-2-en-1-ones through palladium catalyzed hydrogenation in ethanol. The synthesized compounds

Calixarene assembly with enhanced photocurrents using P(SNS-NH2)/CdS nanoparticle structure modified Au electrode systems.

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Prijava / prijava

Two novel calix[n]arene-adorned gold electrodes producing high photocurrent intensities were successfully constructed by embedding gold electrode surfaces with both P(4-(2,5-di(thiophen-2-yl)-1H-pyrrol-1-yl)benzenamine) conducting polymer and 4-mercaptoboronic acid-functionalized semiconductor CdS

Manipulating the proximal triad His-Asn-Arg in human myeloperoxidase.

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Prijava / prijava

In mammalian peroxidases the proximal histidine is in close interaction with a fully conserved asparagine which in turn is hydrogen bonded with an arginine that stabilizes the propionate substituent of pyrrol ring D in bent conformation. In order to probe the role of this rigid proximal architecture

Structural determinants and mechanism of action of a GluN2C-selective NMDA receptor positive allosteric modulator.

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Prijava / prijava

NMDA receptors are tetrameric complexes of GluN1, GluN2A-D, and GluN3A-B subunits and are involved in normal brain function and neurologic disorders. We identified a novel class of stereoselective pyrrolidinone (PYD) positive allosteric modulators for GluN2C-containing NMDA receptors, exemplified by

Cyclodextrin-Polypyrrole Coatings of Scaffolds for Tissue Engineering.

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Prijava / prijava

Polypyrrole is one of the most investigated conductive polymers used for tissue engineering applications because of its advantageous properties and the ability to promote different cell types' adhesion and proliferation. Together with β-cyclodextrin, which is capable of accommodating helpful

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