Experimental: 2 cranberry capsules
2 cranberry capsules: Two cranberry capsules qd (each capsule containing 36mg proanthocyanidin, total 72mg PAC)

2 Cranberry Capsules

Experimental: 2 placebo capsules qd
Placebo: Two placebo capsules qd (each capsule containing 36mg proanthocyanidin, total 72mg PAC)

2 Placebo Capsules

Total

Sex: Female, Male

Race/Ethnicity, Customized

Bacteriuria plus pyuria

Clean catch urine cultures and urinalyses will be obtained every two months for each participant for study purposes.

Participants With Urine Cultures With Bacteriuria (>100,000 Cfu/ml or >=100,000 Cfu/ml) Plus Pyuria (Any WBC)

Suspected UTI episodes that are recorded in the medical record by the primary provider will be reviewed by chart review, symptoms will be recorded, and two adjudicators will determine if the definition of symptomatic UTI is met.

Number of Episodes of Symptomatic UTI

Number of Hospitalizations

Number of Deaths

Chart review will be performed to determine the names and duration of antibiotic prescriptions prescribed by the primary provider on each participant.

Number of Antibiotic Prescriptions

All urine culture data will be reviewed to determine presence of multidrug-resistant gram-negative bacilli (resistance to ≥3 of the following antibiotics: ampicillinsulbactam,cefazolin, ceftriaxone, ceftazidime, fluoroquinolones, piperacillin-tazobactam, meropenem, imipenem, and trimethoprim-sulfamethoxazole).

Bacteriuria With Multidrug-resistant Gram-negative Bacilli

Chart review will be performed to determine the names and duration of antibiotic prescriptions prescribed by the primary provider on each participant's suspected UTI.

Number of Antibiotic Prescriptions for Suspected UTI

Number of Adverse Events in Participants

measured by capsules removed from blister packs

Adherence to Capsule Intake by All Participants

Subjects With 1, 2, or 3 Episodes of UTIs

Overall Study

Dr. Manisha Juthani-Mehta

Bacteriuria

Two cranberry capsules qd (each capsule containing 36mg proanthocyanidin, total 72mg PAC)

2 cranberry capsules

Two placebo capsules qd (each capsule containing 36mg proanthocyanidin, total 72mg PAC)

Placebo

Branford Hills Health Care

Northbridge Health Care Center

Bridgeport Health Care Center

Bridgeport Manor

Riverside Health & Rehabilitation Center

Ludlowe Health Care Center

Glastonbury Health Care Center

The Nathaniel Witherell

Arden House Care and Rehabilitation Center

Hamden Health Care Center

Avery Heights

Wadsworth Glen Health Care and Rehabilitation Center

Water's Edge Center for Health & Rehabilitation

Grimes Center

Mary Wade Home

Advanced Nursing & Rehab Center of New Haven

Shady Knoll Health Center

Lord Chamberlain Nursing & Rehabilitation Center

Village Green of Wallingford

Abbott Terrace Health Center

Hughes Health & Rehab Center

A Trial of Cranberry Capsules for Urinary Tract Infection Prevention in Nursing Home Residents

A Randomized, Controlled Trial of Cranberry Capsules for UTI Prevention in Nursing Home Residents

Yale University

National Institute on Aging (NIA)

Participants were randomized to cranberry or placebo capsules.

Pyuria

Urinary Tract Infections

compound cranberry extract tablet

Min-Sheng General Hospital

Effect of Adjuvant Treatment With Compound Cranberry Extract Tablets in Acute Bacterial Cystitis.

A Double-Blind, Randomized, Placebo-Controlled Study to Evaluate the Effect of Adjuvant Treatment With Compound Cranberry Extract Tablets (UmayC) in Acute Bacterial Cystitis.

Acrobio Healthcare Inc.

pyuria

vaccinium macrocarpon

pyuria/vaccinium macrocarpon

A Trial of Cranberry Capsules for Urinary Tract Infection Prevention in Nursing Home Residents

Effect of Adjuvant Treatment With Compound Cranberry Extract Tablets in Acute Bacterial Cystitis.

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