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raubasine/hypoxia

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ČlankiKliničnih preskušanjPatenti
7 rezultatov
In normoxic rabbits, the intravenous injection (1 mg/kg) of the product (almitrine + raubasine) do not modify the erythrocytic level of 2,3-DPG. But, after hypoxia (the rabbits being submitted to an oxygen pressure of 7,8 kPa during 20 minutes) the same dose of this product induce a durable rise of

Pharmacological features of an almitrine-raubasine combination. Activity at cerebral levels.

Samo registrirani uporabniki lahko prevajajo članke
Prijava / prijava
Treatment with the combination of almitrine-raubasine increases both arterial oxygen partial pressure and haemoglobin oxygen saturation, reflecting an actual increase in the oxygen content of arterial blood. Furthermore, at the trans-cerebral carotid artery/internal jugular vein level, the treatment
Cerebral hemodynamic and metabolic changes, occurring during delayed hypoperfusion following transient cerebral ischemia, and the influence of treatment with almitrine plus raubasine were studied in mongrel dogs. 10 min of transient cerebral ischemia was induced by bilateral clamping of both carotid

Progress in understanding the pathophysiology of cerebral ischemia: the almitrine-raubasine approach.

Samo registrirani uporabniki lahko prevajajo članke
Prijava / prijava
Cerebral ischemia occurs frequently and is disabling. In addition to preventing and correcting risks factors, drugs prevent cell death induced by ischemia-hypoxia. Precise knowledge of the pathophysiology of cerebral ischemia is the prerequisite for drug development, and the main proofs of
Duxil is a combination of almitrine and raubasine. Almitrine produces an increase of PaO2 in arterial blood, and this beneficial effect on hypoxemia is potentiated by that of raubasine on microcirculation. Pharmacological studies of Duxil in healthy animals and experimental models have demonstrated

[Neuronal and astrocytic plasticity: metabolic aspects].

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Prijava / prijava
It is well known that brain function is critically dependent upon energy metabolism and that the brain has a relatively high metabolic rate. Experiments using intact brain preparations do not provide information about metabolism in the different cell types that constitute brain tissue. Progress in
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