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s reticuline/neuroblastoma
Povezava se shrani v odložišče
3 rezultatov
How human neuroblastoma cells make morphine.
Samo registrirani uporabniki lahko prevajajo članke
Prijava / prijava
Recently, our laboratory demonstrated that human neuroblastoma cells (SH-SY5Y) are capable of synthesizing morphine, the major active metabolite of opium poppy. Now our experiments are further substantiated by extending the biochemical studies to the entire morphine pathway in this human cell line.
Mammalian cytochrome P450 enzymes catalyze the phenol-coupling step in endogenous morphine biosynthesis.
Samo registrirani uporabniki lahko prevajajo članke
Prijava / prijava
A cytochrome P450 (P450) enzyme in porcine liver that catalyzed the phenol-coupling reaction of the substrate (R)-reticuline to salutaridine was previously purified to homogeneity (Amann, T., Roos, P. H., Huh, H., and Zenk, M. H. (1995) Heterocycles 40, 425-440). This reaction was found to be
Endogenous formation of morphine in human cells.
Samo registrirani uporabniki lahko prevajajo članke
Prijava / prijava
Morphine is a plant (opium poppy)-derived alkaloid and one of the strongest known analgesic compounds. Studies from several laboratories have suggested that animal and human tissue or fluids contain trace amounts of morphine. Its origin in mammals has been believed to be of dietary origin. Here, we
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