sampangine/amyloidosis

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Inhibitory Potency of 4- Substituted Sampangine Derivatives toward Cu ²⁺ mediated aggregation of amyloid β-peptide, Oxidative Stress, and Inflammation in Alzheimer's Disease

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Prijava / prijava

Cu²⁺ plays a key role in the pathogenesis of Alzheimer's disease (AD). The dysregulation of Cu²⁺ can cause neuronal damage and aggravate development of AD. Moreover, a series of 4-substituted sampangine derivatives have been investigated as inhibitors of acetylcholinesterase

4- Substituted sampangine derivatives: Novel acetylcholinesterase and β-myloid aggregation inhibitors.

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Prijava / prijava

A series of 4- substituted sampangine derivatives (4-aminoalkylaminosampangine Ar-NH(CH2)nNR1R2) has been designed, synthesized, and tested for their ability to inhibit acetylcholinesterase (AChE), butyrylcholinesterase (BChE) and β-myloid (Aβ) aggregation. The synthetic compounds exhibited high

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sampangine/amyloidosis

Inhibitory Potency of 4- Substituted Sampangine Derivatives toward Cu 2+ mediated aggregation of amyloid β-peptide, Oxidative Stress, and Inflammation in Alzheimer's Disease

4- Substituted sampangine derivatives: Novel acetylcholinesterase and β-myloid aggregation inhibitors.

Najbolj popolna baza zdravilnih zelišč, podprta z znanostjo

Inhibitory Potency of 4- Substituted Sampangine Derivatives toward Cu ²⁺ mediated aggregation of amyloid β-peptide, Oxidative Stress, and Inflammation in Alzheimer's Disease