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Stran 1 iz 1239 rezultatov
Treatment of abdominally obese men with a serotonin reuptake inhibitor: a pilot study.
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Prijava / prijava
OBJECTIVE
To investigate the effects of a selective serotonin reuptake inhibitor (SSRI) on the neuroendocrine and autonomic nervous system perturbations found in abdominal obesity.
METHODS
Treatment for 6 months with citalopram and for 6 months with placebo using a double-blind, cross-over design,
Association between serotonin 5-HT-2C receptor gene (HTR2C) polymorphisms and obesity- and mental health-related phenotypes in a large population-based cohort.
Samo registrirani uporabniki lahko prevajajo članke
Prijava / prijava
OBJECTIVE
Studies have shown that common single-nucleotide polymorphisms (SNPs) in the serotonin 5-HT-2C receptor (HTR2C) are associated with antipsychotic agent-induced weight gain and the development of behavioural and psychological symptoms. We aimed to analyse whether variation in the HTR2C is
Prenatal exposure to selective serotonin reuptake inhibitors and risk of childhood overweight.
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Prijava / prijava
The objective was to investigate the association between prenatal selective serotonin reuptake inhibitor (SSRI) exposure and overweight in offspring at 4-5 years of age. We conducted a retrospective cohort study using linked records from the Women's and Children's Health Network in South Australia,
The capsaicin analog nonivamide decreases total energy intake from a standardized breakfast and enhances plasma serotonin levels in moderately overweight men after administered in an oral glucose tolerance test: a randomized, crossover trial.
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Prijava / prijava
METHODS
Since bolus administration of capsaicin has been shown to reduce appetite and ad libitum energy intake, this study elucidated the satiating effect of the less pungent capsaicin analog, nonivamide, on subjective feelings of hunger, ad libitum food intake, and satiating hormones in moderately
Treatment of severe obesity with a highly selective serotonin re-uptake inhibitor as a supplement to a low calorie diet.
Samo registrirani uporabniki lahko prevajajo članke
Prijava / prijava
Inhibitors of serotonin (5HT) re-uptake have generally been successful in inducing modest but statistically significant weight reductions in clinical trials. Citalopram is a new, highly selective inhibitor of 5HT re-uptake. It is effective and safe in relieving major depression at doses up to 60 mg
Hippocampal serotonin mediates hypoactivity in dietarily obese hamsters: a possible manifestation of aging?
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Prijava / prijava
To determine whether endogenous opiates mediate hyperactivity in food restricted hamsters and serotonergic fibers innervating the hippocampus mediate hypoactivity in obese hamsters, food restriction and high-fat diet supplementation were used to produce significant body fat changes (8 vs. 21%). The
Effects of serotonin-depleting midbrain lesions on the defense of hypothalamic obesity.
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Prijava / prijava
Previous research has suggested that lesions of the midbrain dorsal and median raphe nuclei may lower the level at which body weight is regulated in hypothalamic obesity. To test this possibility further, we examined the ability of adult female rats made obese by medial hypothalamic (MH) lesions to
Serotonin-depleting midbrain lesions fail to mitigate hyperphagia and obesity in the Zucker fatty rat.
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Prijava / prijava
Previous research has shown that damage to the dorsal and median raphe nuclei of rats can impede the subsequent development of hypothalamic hyperphagia and obesity as well as impair the defense of established hypothalamic obesity in response to food deprivation. The present study sought to determine
Novel pyrimidoazepine analogs as serotonin 5-HT(2A) and 5-HT(2C) receptor ligands for the treatment of obesity.
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Prijava / prijava
Obesity is one of the most serious public health problems worldwide in the 21st century. Current therapeutic treatment for obesity is mostly focused on preventive measures involving dietary control and physical exercises in combination with anti-obesity medications. However, most of these
Sibutramine: a serotonin-norepinephrine reuptake-inhibitor for the treatment of obesity.
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Prijava / prijava
OBJECTIVE
To review the pharmacology, pharmacokinetics, efficacy data, adverse effects, and drug interactions of sibutramine as a treatment for obesity.
METHODS
English-language clinical studies, abstracts, and review articles were identified using MEDLINE, EMBASE, and a manual search from January
Comparison of brain serotonin transporter using [I-123]-ADAM between obese and non-obese young adults without an eating disorder.
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Prijava / prijava
Cerebral serotonin metabolism has an important but controversial role in obesity. However, it is not given enough attention in morbidly obese young adults. We used single photon emission computed tomography (SPECT) with [I-123]-labeled 2-((2-((dimethylamino)methyl)phenyl)thio)-5-iodophenylamine
Adrenalectomy abolishes the food-induced hypothalamic serotonin release in both normal and monosodium glutamate-obese rats.
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Prijava / prijava
Corticosteroids influence energy homeostasis through centrally-mediated stimulation of energy intake and inhibition of expenditure, while central serotonin (5-HT) has opposite effects. Both serotonergic dysfunction and high glucocorticoid levels may be relevant in obesity. The neurotoxin monosodium
Adrenalectomy increases serotonin turnover in brains of obese Zucker rats.
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Prijava / prijava
Because adrenalectomy tends to normalize many metabolic abnormalities of obese Zucker rats, we hypothesized that it would also normalize the depressed serotonergic turnover in their ventromedial nucleus (VMN). Lean (Fa/Fa) and obese (fa/fa) male Zucker rats were adrenalectomized or sham operated
Use of a serotonin re-uptake inhibitor, fluoxetine, in the treatment of obesity.
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Prijava / prijava
Health risks associated with obesity are well known and compliance with standard regimens for weight reduction is frequently unsatisfactory. Fluoxetine is a specific inhibitor of serotonin re-uptake with very minimal affinity for serotonergic or other receptors. It causes a decrement in food intake
[Differences found in serum serotonin between a group of normal and subjects of obese patients following intravenous tolbutamide administration].
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Prijava / prijava
We have studied the effect of the i.v. administration of 1 g tolbutamide upon glycemia, insulinemia and serotoninemia in normal subjects and obese patients. We have seen an elevation of the last two variables in direct relationship with the previous blood sugar levels. The baseline serotonin level
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