Metabolic Syndrome

22 Patients will consume 600 mg Alpha lipoic acid for 12 weeks .

Alpha lipoic acid

Participants will be supplemented with 600 mg/day placebo (Starch).

Placebo

Alpha Lipoic Acid Supplementation and Metabolic Syndrome

Assessment of the Effect of Alpha Lipoic Acid Supplementation on Inflammatory Factors, Insulin Resistance, Glycemic Control and Anthropometric Indices in Patients With Metabolic Syndrome

Fasting blood glucose concentration (mg/dl)

Serum TG (triacylglycerol) concentration (mg/dl)

Serum TC (total cholesterol) concentration (mg/dl)

Dr. B.Abbasi

Clinical Professor

In this study, samples will be randomly divided into two groups receiving the supplement or placebo.

This study will be conducted as a parallel randomized double-blind clinical trial. patient will randomly be divided into two groups, each will receive supplement or placebo for 12 weeks .Before the study, containers will be coded as A and B by a person other than the study researchers according the concealment rules .

Clinical data including medical history, plain KUB x-ray and renal ultrasound, routine blood work and 24-hour urine collections for all subjects will be collected as part of normal clinical care at routine clinical visit every 4 months.
Subjects in this study arm will be taking one supplement tablet containing 1200 mg of alpha lipoic acid orally once daily for three years.
At the end of the three years of study drug treatment, all subjects will undergo a low dose non-contrast CT scan to look for a silent change in stone size.

Clinical data including medical history, plain KUB x-ray and renal ultrasound, routine blood work and 24-hour urine collections for all subjects will be collected as part of normal clinical care at routine clinical visit every 4 months.
Subjects in this study arm will be taking one placebo tablet containing 10 mg of sucrose orally once daily for three years.
At the end of the three years of study drug treatment, all subjects will undergo a low dose non-contrast CT scan to look for a silent change in stone size.

Cystinuria

Already mentioned in arm/group descriptions.

University of California, San Francisco

Lipoic Acid Supplement for Cystine Stone

The Effect of Lipoic Acid Natural Supplement on Cystine Stone Formation

The primary efficacy endpoint will be assessed in two ways:
symptomatic stone recurrences, defined as renal colic, stone passage, or surgical removal of a stone;
silent stone recurrences, classified as stone growth or new stones, diagnosed on the basis of renal ultrasound, plain KUB x-ray, or if clinically indicated, computed tomography.

The secondary endpoints will be quantitative urinary cystine level determined by 24-hour urine collection.

thioctic acid/rak

Alpha Lipoic Acid Supplementation and Metabolic Syndrome

Lipoic Acid Supplement for Cystine Stone

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