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Skin irritant and tumor promoting diterpene esters of the tigliane type from the Chinese tallow tree (Sapium sebiferum).

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[A study on the promoting effect of Sapium sebiferum and Wisktroemia indica on experimental cervical cancer in mice].

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Toxic phorbol esters from Chinese tallow stimulate protein kinase C.

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Phorbol esters were isolated from the seeds of Chinese tallow (Sapium sebiferum L. Roxb.). These compounds were based on the tigliane nuclei, 4-deoxyphorbol, 12-deoxyphorbol and 4,20-dideoxy-5-hydroxyphorbol. The pro-inflammatory activity (ID50) of the pure compounds was between 0.042 and 2.6 nmoles

A review of the medicinal uses, phytochemistry and pharmacology of the genus Sapium.

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BACKGROUND Several species from the genus Sapium possess a broad range of medicinal properties and they have been used as traditional medicines by indigenous groups in several regions such as Malaysia, Africa, Southern China and Bolivia. Most of the species reported to possess therapeutic effects

Plant-derived diterpene esters enhance HTLV-I-induced colony formation of lymphocytes in co-culture.

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The addition to culture dishes of 10-50 ng/ml of the essential diterpene ester of Sapium sebiferum, 12-O-hexadecanoylphorbol-13-acetate (HPA), increased colony formation of normal peripheral blood lymphocytes co-cultured with gamma-irradiated HTLV-I-producing HUT 102 cells. The cells in the

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