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New therapeutic strategy of hinokitiol in haemorrhagic shock-induced liver injury.

Samo registrirani uporabniki lahko prevajajo članke

Prijava / prijava

Haemorrhagic shock and resuscitation (HS/R) may cause global ischaemia-reperfusion injury, which can result in systemic inflammation, multiorgan failure (particularly liver failure) and high mortality. Hinokitiol, a bioactive tropolone-related compound, exhibits antiplatelet and anti-inflammatory

[Antiplatelet effects of combination therapy with low-dose aspirin and ticlopidine in cerebral ischemia].

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Prijava / prijava

Antiplatelet effects of combination therapy with aspirin and ticlopidine were investigated in comparison with single aspirin or ticlopidine therapy in 62 patients with cerebral thrombosis or transient ischemic attack. The 14, 21 and 27 patients were given orally daily aspirin 300mg, ticlopidine

Effect of U88999E on experimental cerebral vasospasm in rabbits.

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Prijava / prijava

U88999E, 7-[4,(4, 4'-difluorobenzhydryl)piperazino-1-methyl]-4- isopropyl-2-methoxy-2,4,6-cycloheptatrien-1-one hydrochloride, is a recently developed tropolone derivative that inhibits lipid peroxidation and also acts as a calcium antagonist. The effects of U88999E on basilar artery tone were

Homing and circulation of indium-111-labelled leucocytes. A post-mortem study.

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Prijava / prijava

The history of a patient with a suspected ischemic brain infarct undergoing an indium-111-tropolone white cell labelled test is reported. The patient, who died 12 h after injection of the labelled cells, suffered of a brain haemorrhage. The post-mortem examination has allowed for the first time the

Posttraumatic cerebral ischemia after fluid percussion brain injury: an autoradiographic and histopathological study in rats.

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Prijava / prijava

OBJECTIVE Mild-to-moderate reductions in local cerebral blood flow (ICBF) have been reported to occur in rats after moderate (1.7-2.2 atm) fluid percussion brain injury. The purpose of this study was to determine whether evidence for severe ischemia (i.e., mean ICBF < 0.25 ml/g/min) could be

Uptake, metabolism and release of (3H)-adrenaline by human platelets.

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Prijava / prijava

1. Measurements were made of the uptake, metabolism and release of [(3)H]-adrenaline by human platelets in citrated plasma or in an artificial medium.2. Radioactive adrenaline was not taken up at 0-2 degrees C. At 37 degrees C there was a slow uptake which continued for at least 5 hours.3. About

[Pharmacological therapeutic prospects of cerebral vasospasm].

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Prijava / prijava

New therapies of cerebral vasospasm aim to prevent the effects of subarachnoid haemorrhage. These effects result in red blood cell haemolysis and release of oxyhaemoglobin, free radicals formation and lipid peroxidations, imbalance in endothelial modulation of vasomotor tone and activation of the

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