tryptophane/epileptični krč

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Doxycycline could aggravate the absence-like epileptic seizures of WAG/Rij rats via matrix metalloproteinase inhibition.

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Prijava / prijava

Matrix metalloproteinases (MMPs) are known to be activated in the brain by epileptic seizures and elevated MMP-9 activity has been found in a genetic model of generalized absence epilepsy (Wistar Albino Glaxo Rijswijk/WAG/Rij rats). In this study we posed the question, whether MMP inhibitory dose of

[The role of mediators in the genesis of convulsive activity. Biogenic monoamine content of the brain of rats with various predispositions to audiogenic convulsions].

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Content of serotonin, tryptophane, adrenaline, noradrenaline, dopamine, DOPA and tyrosine in was studied in cerebellum, truncus cerebri, hypothalamus and brain hemispheres of rats with various predisposition to audiogenic convulsions. Distinct decrease in content of brain serotonin, noradrenaline

[Elevated kynurenine concentration in the blood serum of children with epilepsy and bronchial asthma].

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Prijava / prijava

A total of 84 children were investigated: 15 with bronchial asthma, 41 with combined seizure and bronchial obstruction syndrome, 14 with epilepsy. The kynurenine blood level was found to correlate with seizures. It was highest in epilepsy (5.27 +/- 0.99 nM/ml) together with the lowest dioxygenase

Modulation of sodium current in mammalian cells by an epilepsy-correlated beta 1-subunit mutation.

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The syndrome of generalized epilepsy with febrile seizure plus (GEFS+) is associated with a single point mutation on the gene SCN1B that results in a substitution of the cysteine 121 with a tryptophane in the sodium channel beta 1-subunit protein. We have studied, in the HEK cells permanently

Two novel mutations of ornithine transcarbamylase gene identified from three Chinese neonates with ornithine transcarbamylase deficiency.

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Prijava / prijava

We aim to analyze the blood metabolic profiling and the gene mutation of ornithine transcarbamylase (OTC) in three neonates with ornithine transcarbamylase deficiency (OTCD). Three neonates with OTCD were included in this study. The profiling of amino acids and acylcarnitine was determined using

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