uricase/hypoxia

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Biochemical measurement of neonatal hypoxia.

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Prijava / prijava

Neonatal hypoxia ischemia is characterized by inadequate blood perfusion of a tissue or a systemic lack of oxygen. This condition is thought to cause/exacerbate well documented neonatal disorders including neurological impairment. Decreased adenosine triphosphate production occurs due to a lack of

Urate produced during hypoxia protects heart proteins from peroxynitrite-mediated protein nitration.

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Prijava / prijava

Tyrosine nitration is a common modification to proteins in vivo, but the reactive nitrogen species responsible for nitration are often studied in vitro using just the amino acid tyrosine in simple phosphate solutions. To investigate which reactive nitrogen species could nitrate proteins in a complex

Status of glutathione in the rat liver. Enhanced formation of oxygen radicals at low oxygen tension.

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Prijava / prijava

Rat livers were initially perfused and then stored at various temperatures up to 4 h. The intra- and extrahepatic status of glutathione, the accumulation of hydrogen peroxide in the preservation medium, the action of a OH-scavenger and of a xanthine oxidase-inhibitor were investigated as candidates

H2O2 formation during nucleotide degradation in the hypoxic rat liver: a quantitative approach.

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Prijava / prijava

In the hypoxic liver an increased rate of cytosolic and peroxisomal H2O2 generation is due to the accelerated purine nucleotide degradation. The relative contribution of the oxidase type of xanthine oxidoreductase activity increases in hypoxia by less than 10%, the dehydrogenase type of this enzyme

Soluble Uric Acid Promotes Atherosclerosis via AMPK (AMP-Activated Protein Kinase)-Mediated Inflammation.

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Prijava / prijava

Uric acid is supposed but not yet determined to be associated with atherosclerosis. Uric acid is released from damaged cells to form urate crystal, which is recognized by the immune system to produce IL (interleukin)-1. Danger signals and IL-1 have been shown to play an important role

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