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9 rezultatov
The effects of bromvincamine and vincamine on regional cerebral blood flow and mental functions in patients with multi-infarct dementia.
Samo registrirani uporabniki lahko prevajajo članke
Prijava / prijava
The effects of vincamine and bromvincamine (BV 26-723) on mental functions and regional cerebral blood flow (rCBF) measured by the 133Xe inhalation method, were investigated in ten patients with mild to severe symptoms of multi-infarct dementia. The double blind cross over design included three
The effects of vincamine on experimental cerebral infarction in Mongolian gerbils: a pilot study.
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Prijava / prijava
Unilateral ligation of the common carotid artery was performed in 134 gerbils. Study I was comprised of 60 controls and 60 animals receiving I.P. vincamine 1 mg/kg q4h. In a small second study 14 animals received vincamine I.P. 40 mg/kg q12h. In all groups ligation of the carotid artery was
Experimental cerebral infarction in Mongolian gerbils: effects of vincamine on lesion size, survival and behavior.
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Prijava / prijava
Vincamine was administered to gerbils at doses of 0, 1, 2, 10 and 40 mg/kg/d to study its effect on survival, extent of ischemic brain lesion, locomotor activity, neurologic signs, stool production, and food and water intake after unilateral carotid occlusion. Drug and placebo were delivered by
Therapeutic efficacy of vincamine in dementia.
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Prijava / prijava
This trial was performed to investigate the therapeutic efficacy of vincamine in the treatment of primary degenerative and vascular dementia. 152 male and female patients aged between 50 and 85 years from two psychogeriatric centers and two nursing homes were initially included in the trial and
Pharmaco-EEG study on vincamine and on teproside in patients with chronic cerebrovascular disease.
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Prijava / prijava
Pharmaco-EEG is a technique used in diagnostic and in neuropharmacological research. Correlations between the ageing brain and EEG spectral analysis have been discovered (1-5). Typical EEG findings of multi-infarct dementia, senile dementia and chronic cerebrovascular disease have been reported by
[Nicergoline and steal effect in favor of zones of hypoperfusion in cerebral ischemic accidents].
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Prijava / prijava
Hemispheric and regional variations of cerebral blood flow (CBF) were studied with the Xenon inhalation technique on 19 patients suffering from cerebral infarcts before and at the end of a 10 mg 'alpha-blocking' Nicergoline perfusion. CBF dynamic images and calculations were performed with a gamma
Vinpocetine attenuates lipid accumulation and atherosclerosis formation.
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Prijava / prijava
Atherosclerosis, the major cause of myocardial infarction and stroke, is a chronic arterial disease characterized by lipid deposition and inflammation in the vessel wall. Cholesterol, in low-density lipoprotein (LDL), plays a critical role in the pathogenesis of atherosclerosis. Vinpocetine, a
Effects of agents used in the pharmacotherapy of cerebrovascular disease on the oxygen consumption of isolated cerebral mitochondria.
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Prijava / prijava
A number of drugs used in the pharmacotherapy of cerebral metabolic and vascular disease have been studied for their effects on the respiration of mitochondria isolated from the rat brain. Some of these agents increased the respiratory control ratio by more than 5% from base-line values (at p less
Vinpocetine alleviate cerebral ischemia/reperfusion injury by down-regulating TLR4/MyD88/NF-κB signaling.
Samo registrirani uporabniki lahko prevajajo članke
Prijava / prijava
Inflammatory responses play crucial roles in cerebral ischemia/reperfusion injury. Toll-like receptor 4 (TLR4) is an important mediator of the neuroinflammatory response to cerebral ischemia/reperfusion injury. Vinpocetine is a derivative of the alkaloid vincamine and exerts an anti-inflammatory
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