vobasine/tabernaemontana

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Vobatensines A-F, Cytotoxic Iboga-Vobasine Bisindoles from Tabernaemontana corymbosa.

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Prijava / prijava

Six new bisindole alkaloids of the iboga-vobasine type, vobatensines A-F (1-6), in addition to four known bisindoles (8-11), were isolated from a stem bark extract of a Malayan Tabernaemontana corymbosa. The structures of these alkaloids were determined based on analysis of the spectroscopic data

Cytotoxic vobasine, tacaman, and corynanthe-tryptamine bisindole alkaloids from Tabernaemontana and structure revision of tronoharine.

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Prijava / prijava

Seven new indole alkaloids (1-7) comprising four vobasine, two tacaman, and one corynanthe-tryptamine bisindole alkaloid were isolated from the stem-bark extract of a Malayan Tabernaemontana. Two of the new vobasine alkaloids (1, 3), as well as 16-epivobasine (15) and 16-epivobasenal (17), showed

Conodiparines A-D, new bisindoles from Tabernaemontana. Reversal of vincristine-resistance with cultured cells.

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Prijava / prijava

Four new bisindoles of the vobasine-iboga type, conodiparines A-D were obtained from Tabernaemontana corymbosa which showed appreciable activity in reversing resistance in vincristine-resistant KB cells.

Accumulation of indole alkaloids in a suspension culture of Tabernaemontana divaricata.

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Prijava / prijava

Cell suspension cultures of TABERNAEMONTANA DIVARICATA were found to produce relatively large amounts of indole alkaloids. For their isolation an ion-pair DCCC method was used in combination with preparative TLC. The alkaloids were identified as tabernaemontanine, perivine, vobasine, voaphylline,

Characterization of a Suspension Culture of Tabernaemontana elegans on Growth, Nutrient Uptake, and Accumulation of Indole Alkaloids*.

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Prijava / prijava

A suspension culture of TABERNAEMONTANA ELEGANS was characterized on growth, nutrient uptake (carbohydrate, nitrogen, and phosphate), and on accumulation of indole alkaloids. Besides tryptamine seven indole alkaloids were isolated and identified: vobasine, vobasinol, perivine, isositsirikine,

Tertiary indole alkaloids from leaves of Tabernaemontana dichotoma.

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Prijava / prijava

Seven indole alkaloids were isolated and identified from the leaves of Tabernaemontana dichotoma Roxb. The major alkaloids were: perivine, 19-epi-voacristine, 12-methoxy-voaphylline and vobasine. (-)apparicine, 19-epi-iboxygaine and isomethuenine occurred in minor amounts.

Muscle relaxant activity and hypotensive activity of some Tabernaemontana alkaloids.

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Prijava / prijava

Stemmadenine, the major alkaloid from the seeds of Tabernaemontana dichotoma, showed hypotensive activity and weak muscle relaxant activity. Perivine, vobasine, coronaridine and dichomine, some of the alkaloids found in the leaves, fruits and bark of T. dichotoma, also showed hypotensive and muscle

Induction of apoptosis in HuH-7 cancer cells by monoterpene and beta-carboline indole alkaloids isolated from the leaves of Tabernaemontana elegans.

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Prijava / prijava

Three known (1-3) and a novel (4) monoterpene indole alkaloids have been isolated from the methanol extract of leaves of Tabernaemontana elegans and their structures were elucidated by a series of spectroscopic experiments, involving NMR, MS, UV, and IR techniques. The isolated monoterpene indole

Plant anticancer agents III: Isolation of indole and bisindole alkaloids from Tabernaemontana holstii roots.

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Prijava / prijava

Certain active antileukemic and cytotoxic fractions prepared from Tabernaemontana holstii roots were investigated, resulting in the isolation of the known indole alkaloids conoduramine, conodurine, coronaridine, gabunine, 19-oxocoronaridine, pericyclivine, perivine, and vobasine. Two new alkaloids

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