Aminophylline for Patients With Post-Dural Puncture Headache
Fjalë kyçe
Abstrakt
Datat
Verifikuar së fundmi: | 09/30/2016 |
Paraqitur së pari: | 08/07/2015 |
Regjistrimi i vlerësuar u dorëzua: | 08/11/2015 |
Postuar së pari: | 08/12/2015 |
Përditësimi i fundit i paraqitur: | 10/26/2016 |
Përditësimi i fundit i postuar: | 10/30/2016 |
Data e fillimit të studimit aktual: | 09/30/2015 |
Data e vlerësuar e përfundimit primar: | 09/30/2016 |
Data e vlerësimit të përfundimit të studimit: | 09/30/2016 |
Gjendja ose sëmundja
Ndërhyrja / trajtimi
Drug: Aminophylline group
Drug: isotonic saline group
Faza
Grupet e krahëve
Krah | Ndërhyrja / trajtimi |
---|---|
Experimental: Aminophylline group IV injection of aminophylline | Drug: Aminophylline group |
Placebo Comparator: isotonic saline group IV injection of isotonic saline group | Drug: isotonic saline group |
Kriteret e pranimit
Moshat e pranueshme për studim | 18 Years Për të 18 Years |
Gjinitë e pranueshme për studim | All |
Pranon Vullnetarë të Shëndetshëm | po |
Kriteret | Inclusion Criteria: - headache has developed after the dural puncture; - PDPH was defined according to the International Classification of Headache Disorders III (ICHD-3) criteria; - The VAS score of the headache was 5 or more than 5; - age between 18 and 70 years old. Exclusion Criteria: - a previous history of headache that could interfere with PDPH diagnosis; - a history of central nervous system diseases including intracranial hemorrhage, seizures, intracranial hypertension, and hydrocephalus; - a history of cardiovascular system diseases including coronary heart disease, arrhythmias, and hypertension; - a history of peptic ulcer. - women who were pregnant, nursing, or planning a pregnancy. |
Rezultati
Masat Kryesore të Rezultateve
1. pain on the Visual Analogue Scale [baseline phase]
2. pain on the Visual Analogue Scale [0.5 hour after the Intervention]
3. pain on the Visual Analogue Scale [1 hour after the Intervention]
4. pain on the Visual Analogue Scale [8 hours after the Intervention]
5. pain on the Visual Analogue Scale [1 day after the Intervention]
6. pain on the Visual Analogue Scale [2 days after the Intervention]
Masat dytësore të rezultateve
1. the overall response to treatment on the Patient Global Impression of Change [2 days after the Intervention]
Masat e tjera të rezultateve
1. safety (occurrence of adverse reactions) [Participants will be followed for the duration of hospital stay, an expected average of 7 days]