Brown Fat Activity and White Fat Accumulation

Vetëm përdoruesit e regjistruar mund të përkthejnë artikuj

Identifikohuni Regjistrohu

Lidhja ruhet në kujtesën e fragmenteve

StatusiPërfunduar

Sponsorët

Children's Hospital Los Angeles

TRAJTIM KLINIKAL: NCT01517581

BioSeek: NCT01517581

Fjalë kyçe

Abstrakt

White and brown adipocytes differ in their expression of hormones, cytokines, and inflammatory factors, and they modulate different biological functions. While white adipose tissue (WAT) serves as the primary site of energy storage, brown adipose tissue (BAT) instead metabolizes fat to produce heat and regulate body temperature. BAT is likely present in all humans, but the low prevalence of BAT depiction in adults and elderly subjects has hindered longitudinal assessments of the relation between BAT activity and WAT. Under typical imaging conditions, BAT is detected more frequently in children and teenagers than in adults with malignancy. Since most children with cancer have significantly shorter treatment courses and greater survival rates compared to adult patients, the investigators have the ability to examine the relation of repeated measures of body composition and BAT by selecting pediatric patients. In this study, the investigators will longitudinally examine whether BAT activity is related to changes in weight and the amounts of SAT, VAT, and abdominal muscle in children successfully treated for pediatric cancer.

Datat

Verifikuar së fundmi:	12/31/2011
Paraqitur së pari:	01/19/2012
Regjistrimi i vlerësuar u dorëzua:	01/23/2012
Postuar së pari:	01/24/2012
Përditësimi i fundit i paraqitur:	01/23/2012
Përditësimi i fundit i postuar:	01/24/2012
Data e fillimit të studimit aktual:	09/30/2008
Data e vlerësuar e përfundimit primar:	08/31/2011
Data e vlerësimit të përfundimit të studimit:	08/31/2011

Gjendja ose sëmundja

Hodgkins Lymphoma

Non-hodgkins Lymphoma

Faza

Grupet e krahëve

Krah	Ndërhyrja / trajtimi
Malignant Disease with no visualized BAT Children 18 years or younger who 1) had PET/CT scans with evidence of malignant disease but no metabolically active brown adipose tissue (BAT) at diagnosis and 2) were disease free within 1 year of diagnosis.

Kriteret e pranimit

Moshat e pranueshme për studim	6 Years Për të 6 Years
Gjinitë e pranueshme për studim	All
Metoda e marrjes së mostrës	Non-Probability Sample
Pranon Vullnetarë të Shëndetshëm	po
Kriteret	Inclusion Criteria: - Patients had PET/CT scans with evidence of malignant disease - Patients had no metabolically active BAT at diagnosis on their PET/CT scan - Patients were disease free within 1 year of diagnosis Exclusion Criteria: - Patients had PET/CT scans with no evidence of malignant disease - Patients with metabolically active BAT at diagnosis on their PET/CT scan - Patients were not disease free within 1 year of diagnosis

Rezultati

Masat Kryesore të Rezultateve

1. Change from Baseline in Subcutaneous Adipose Tissue Volume at Follow-up [Baseline and up to 1 year]

2. Change from Baseline in Visceral Adipose Tissue Volume at Follow-up [Baseline and up to 1 year]

3. Change from Baseline in Presence of Brown Adipose Tissue [Baseline and up to 1 year]

4. Change from Baseline in Abdominal Musculature Volume [Baseline and up to 1 year]

Masat dytësore të rezultateve

1. Change from Baseline in Anthropometric Measures at Follow-up [Baseline and up to 1 year]

Age, height, weight and BMI