Cerebral Infarction and White Substance in Angiopathy Cerebral Amyloid
Vetëm përdoruesit e regjistruar mund të përkthejnë artikuj
Identifikohuni Regjistrohu
Lidhja ruhet në kujtesën e fragmenteve
StatusiPërfunduar
Sponsorët
Groupe Hospitalier Paris Saint Joseph
TRAJTIM KLINIKAL: NCT03262246
BioSeek: NCT03262246
Fjalë kyçe
Abstrakt
The cerebral amyloïd angiopathy ( AAC) is a disease characterized by deposits of beta-amyloid peptids in the walls of the arteries of young and average calibre of the brain and the leptomeninx. The incidence of the AAC increases strongly with the age and represents a major cause of spontaneous brain haemorrhage to people over 60. The main demonstration is the lobar brain haemorrhage, the other ones are bleedings under arachnoid cortical and microbleedings leading to cognitive decline.
Anatomical studies reported the presence of cortical infarcts in patients having amyloïd deposits suggesting an association between asymptomatic cortical cerebral infarcts and AAC.
However prevalence and meaning of these infarcts in patients having an AAC remain badly known because of studies on low number of patients and the rarity of radiological analyses of these infarcts .A better knowledge of these asymptomatic cortical infarcts would allow to dread better cognitive disorders(confusions) presented by these patients, and to develop preventive strategies.
Besides, the risk factors of severity of the AAC are little studied.
Datat
| Verifikuar së fundmi: | 07/31/2018 |
| Paraqitur së pari: | 08/23/2017 |
| Regjistrimi i vlerësuar u dorëzua: | 08/23/2017 |
| Postuar së pari: | 08/24/2017 |
| Përditësimi i fundit i paraqitur: | 01/31/2019 |
| Përditësimi i fundit i postuar: | 02/03/2019 |
| Data e fillimit të studimit aktual: | 06/01/2016 |
| Data e vlerësuar e përfundimit primar: | 12/30/2016 |
| Data e vlerësimit të përfundimit të studimit: | 12/30/2018 |
Gjendja ose sëmundja
Amyloid Angiopathy
Ndërhyrja / trajtimi
Other: medical report consultation
Faza
-
Kriteret e pranimit
| Moshat e pranueshme për studim | 55 Years Për të 55 Years |
| Gjinitë e pranueshme për studim | All |
| Metoda e marrjes së mostrës | Probability Sample |
| Pranon Vullnetarë të Shëndetshëm | po |
| Kriteret | Inclusion Criteria: - age>55 - hospitalized in CAEN hospital and Paris St Joseph Hospital between 1st january 2011 and 31 december 2015 for cerebral haemorrhage with MRI images diagnosing cerebral amyloid angiopathy. Exclusion Criteria: - Insufficient MRI images quality without FLAI sequence, T2 GRE - disease with same radiologic and clinical signs that cerebral amyloid angiopathy. |
Rezultati
Masat Kryesore të Rezultateve
1. number of patient with cerebral infarction and associated factors in a cohort of cerebral amyloid angiopathy patients [1day]
