Detection and Characteristic of Whipple Diseases in the Great Britany
Vetëm përdoruesit e regjistruar mund të përkthejnë artikuj
Identifikohuni Regjistrohu
Lidhja ruhet në kujtesën e fragmenteve
StatusiPërfunduar
Sponsorët
University Hospital, Brest
TRAJTIM KLINIKAL: NCT03350685
BioSeek: NCT03350685
Fjalë kyçe
Abstrakt
Whipple's disease is a chronic systemic infection caused by ubiquitous bacterium Tropheryma wipplei on a genetic predisposition which should be considered in patients with recurrent episodes of seronegative arthritis, erosive or not, or inflammatory low back pain, chronic diarrhea, persistent fever, unexplained neurological signs, uveitis, endocarditis, and epithelioid granuloma.
Laboratory tests may show malabsorption, erythrocyte sedimentation rate and C-reactive protein elevation, anemia, thrombocytosis, eosinophilia and lymphopenia.
None of theses findings is specific and most patients have arthritis or low back pain mimicking rheumatoid arthritis and spondyloarthritis.
As the disease is rare, chance for positive polymerase chain reaction testing for Tropheryma whipplei is low in this context.
Datat
| Verifikuar së fundmi: | 01/31/2018 |
| Paraqitur së pari: | 11/16/2017 |
| Regjistrimi i vlerësuar u dorëzua: | 11/20/2017 |
| Postuar së pari: | 11/21/2017 |
| Përditësimi i fundit i paraqitur: | 02/11/2018 |
| Përditësimi i fundit i postuar: | 02/12/2018 |
| Data e fillimit të studimit aktual: | 11/14/2017 |
| Data e vlerësuar e përfundimit primar: | 02/08/2018 |
| Data e vlerësimit të përfundimit të studimit: | 02/08/2018 |
Gjendja ose sëmundja
Whipple Disease
Faza
-
Grupet e krahëve
| Krah | Ndërhyrja / trajtimi |
|---|---|
| Classic Whipple's disease (CWD) Classic Whipple's disease (CWD), defined as
duodenal biopsy positive by PAS/immunohistochemistry
or blood positive by PCR | |
| Focal Whipple's disease (FWD) Focal Whipple's disease (FWD), defined as
joint fluid positive by PCR
but duodenal biopsy negative by PAS/immunohistochemistry | |
| Chronic T. whipplei-associated arthritis (CTWA) Chronic T. whipplei-associated arthritis (CTWA) defined as chronic arthritis and
duodenal biopsy, stool, or saliva positive by PCR
duodenal biopsy negative by PAS/immunohistochemistry
joint fluid negative by PCR |
Kriteret e pranimit
| Moshat e pranueshme për studim | 18 Years Për të 18 Years |
| Gjinitë e pranueshme për studim | All |
| Metoda e marrjes së mostrës | Probability Sample |
| Pranon Vullnetarë të Shëndetshëm | po |
| Kriteret | Inclusion Criteria: - Adult - patient with at least a screening test for Whipple'disease - participation agreement, Exclusion Criteria: - No test for Whipple'disease |
Rezultati
Masat Kryesore të Rezultateve
1. Number of patients diagnosed as whipple's disease [Day 0 ( Date of diagnostic)]
Diagnosis of Whipple's disease based on
at least one suggestive clinical finding
at least one test detecting T. Whipplei
diagnosis made by a specialist
a dramatic and persistent response to antibiotic therapy
Hydroxychloroquine 200mgx2 plus Doxycycline 100mgx2
or trimethoprim/sulfamethoxazole 800/160mg x2
Masat dytësore të rezultateve
1. Number of test performed in each centre [Day 0 (Date of diagnostic)]
Number of diagnoses according to tests
Patients will be divided into three groups
Classic Whipple's disease (CWD), defined as :
duodenal biopsy positive by PAS/immunohistochemistry
or blood positive by PCR
Focal Whipple's disease (FWD)
joint fluid positive by PCR
but duodenal biopsy negative by PAS/immunohistochemistry
Chronic T. whipplei-associated arthritis (CTWA): chronic arthritis and
duodenal biopsy, stool, or saliva positive by PCR
duodenal biopsy negative by PAS/immunohistochemistry
joint fluid negative by PCR
