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Body Composition and White Adipose Tissue Inflammation

Vetëm përdoruesit e regjistruar mund të përkthejnë artikuj
Identifikohuni Regjistrohu
Lidhja ruhet në kujtesën e fragmenteve
StatusiRekrutimi
Sponsorët
Memorial Sloan Kettering Cancer Center
Bashkëpunëtorë
Weill Medical College of Cornell University

Fjalë kyçe

Abstrakt

The investigators want to find a better way to predict the risk of having fatty tissue inflammation by using a different approach to finding out body fat composition. In this study, the investigators want to estimate the body fat composition using a DEXA scan. DEXA stands for dual energy X-ray absorptiometry. It is the standard and established test to determine bone mineral density (how strong the bones are) to diagnose osteoporosis. This test can also be used to determine the body composition including percent body fat and lean mass. The investigators will compare the participants DEXA scan results for body fat composition to the inflammation found in the breast tissue from the mastectomy to see if there is a relationship. If successful, this may help us predict which patients may be at risk for breast cancer in the future. In addition, the investigators will compare the participants DEXA scan results for body fat composition and inflammation found in the fat tissue from the mastectomy or prostatectomy to the level of exercise activity as measured by a short questionnaire to see if there is a relationship. The investigators will also measure the participants waist to hip ratio.
Finally, at the time the participant has blood drawn for their standard presurgical testing, the investigators will also test the blood for prediabetes using a blood test called hemoglocin A1c. The investigators will also measure for the participants waist to hip ratio, and a Hgb A1c blood drawn will be take at the time of presurgical testing. If not feasible, Hgb A1c can be drawn at a separate visit prior to the DEXA scan. If successful, this may help us predict which patients may be at risk for breast cancer in the future.

Datat

Verifikuar së fundmi: 03/31/2020
Paraqitur së pari: 03/10/2016
Regjistrimi i vlerësuar u dorëzua: 03/14/2016
Postuar së pari: 03/17/2016
Përditësimi i fundit i paraqitur: 04/06/2020
Përditësimi i fundit i postuar: 04/07/2020
Data e fillimit të studimit aktual: 11/03/2015
Data e vlerësuar e përfundimit primar: 10/31/2021
Data e vlerësimit të përfundimit të studimit: 10/31/2021

Gjendja ose sëmundja

Breast Cancer
Prostate Cancer
Body Composition
White Adipose Tissue Inflammation

Ndërhyrja / trajtimi

Device: DEXA Scan

Behavioral: Godin Leisure Time Exercise Questionnaire (GLTEQ)

Faza

-

Grupet e krahëve

KrahNdërhyrja / trajtimi
Breast Cancer
DEXA scan will be carried out 1 to 30 days prior to mastectomy. Patients will also complete the Godin Leisure Time Exercise Questionnaire (GLTEQ) and their waist to hip ratio will be measured.
Prostate Cancer
DEXA scan will be carried out 1 to 30 days prior to radical prostatectomy. Patients will also complete the Godin Leisure Time Exercise Questionnaire (GLTEQ) and their waist to hip ratio will be measured.

Kriteret e pranimit

Moshat e pranueshme për studim 18 Years Për të 18 Years
Gjinitë e pranueshme për studimAll
Metoda e marrjes së mostrësNon-Probability Sample
Pranon Vullnetarë të Shëndetshëmpo
Kriteret

Inclusion Criteria:

- Age ≥ 18

- Female

- All BMIs

- Patients undergoing mastectomy at MSKCC (i.e. Nipple-sparing mastectomy, skin-sparing mastectomy, simple mastectomy, modified radical mastectomy, radical mastectomy); mastectomy may be either prophylactic or therapeutic. OR

- Patients undergoing hysterectomy at MSKCC

- History of prior breast surgeries/procedures is acceptable

Exclusion Criteria:

- Pregnancy (confirmed or suspected);

- Inability to lay supine on equipment table and maintain the position for the necessary time;

- Weight superior to the maximum allowed by the DEXA machine (over 350 lbs or 158 kg);

- Greater than 10% baseline weight loss in the past year;

- Planned surgical procedure is not a Mastectomy (i.e. breast conservation surgery or other non-mastectomy procedure; such as lumpectomy) or hysterectomy

- Metastatic cancer

- History of Wasting Syndromes or Cachexia

- Use of daily NSAIDs, aspirin, or steroids (other than inhaled or topical) within 30 days of surgery

- Use of neoadjuvant systemic or radiation therapy.

Rezultati

Masat Kryesore të Rezultateve

1. fat percentage [1 year]

as measured by DEXA

2. presence of White Adipose Tissue Inflammation (WATi ) [1 year]

as measured by DEXA

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