Heart Aging When Near Vision Difficulty Begins

Vetëm përdoruesit e regjistruar mund të përkthejnë artikuj

Identifikohuni Regjistrohu

Lidhja ruhet në kujtesën e fragmenteve

StatusiPërfunduar

Sponsorët

Kecioren Education and Training Hospital

TRAJTIM KLINIKAL: NCT04362215

BioSeek: nct04362215

Fjalë kyçe

Abstrakt

Near vision deterioration during aging results from a decrease in accomodation amplitude (AA). Myocardial regeneration is limited, and cardiac aging is an independent risk factor for cardiovascular disease. Thus, the investigators investigated the association between cardiac aging and AA.

The subjects (500, mean 50-year-old subjects, with equal males and females) were divided into two groups according to AA measured with a Raf ruler. Biomicroscopy was used to capture images of the lens nucleus in the unaccommodated state, followed by images of a 4 diopter (D) accommodated state. The nucleus diameter change at 1 D accomodation was measured using ImageJ. Cardiac conduction system differences were evaluated using electrocardiography, and cardiac autonomic aging was assessed based on heart rate variability. Myocardial aging was assessed based on diastolic dysfunction.

Përshkrim

Lens cells and proteins are encapsulated, and they are not turned over or replaced.The lens nucleus starts to form before birth, so the nucleus is one of the three oldest tissues in the body .With aging, continuous cardiomyocyte stress derails proteostasis by causing excessive autophagy and protease activation, and, ultimately, contractile and electrophysiological dysfunction. Aggregate deposition, proteostasis deterioration, and diffusion degradation between the nucleus and cortex are the main reasons for lens aging.Heart, lens, and neuronal cells change significantly with age, and they are older than cells from renewable tissues.

Near vision deterioration during aging results from a decrease in accomodation amplitude (AA). Cardiac aging is an independent risk factor for cardiovascular disease. Thus, the investigators investigated the association between cardiac aging and AA. The subjects (500 mean 50-year-old subjects, with equal males and females) were divided into two groups according to AA measured with a Raf ruler. The nucleus diameter change at 1 D accomodation was measured using ImageJ. Cardiac conduction system differences, autonomic aging, myocardial aging were evaluated using electrocardiography, heart rate variability and diastolic dysfunction. For near distance vision,compared to subjects who could see clearly from 24-28 cm, subjects who could see clearly from 29-33 cm had a 2.104-fold higher risk of a lateral e' velocity <10 cm/s[95%CI; 1.312-3.374], 2.603-fold higher risk of diastolic dysfunction[95%CI; 1.453-4.662], 1.54-fold higher risk of a low/high frequency ratio >3.1, [95%CI;1.085-2.197]. Subjective AA measurement can predict important heart aging parameters.

Datat

Verifikuar së fundmi:	03/31/2020
Paraqitur së pari:	04/19/2020
Regjistrimi i vlerësuar u dorëzua:	04/22/2020
Postuar së pari:	04/23/2020
Përditësimi i fundit i paraqitur:	04/22/2020
Përditësimi i fundit i postuar:	04/23/2020
Data e fillimit të studimit aktual:	09/09/2019
Data e vlerësuar e përfundimit primar:	03/14/2020
Data e vlerësimit të përfundimit të studimit:	03/14/2020

Gjendja ose sëmundja

Aging

Ndërhyrja / trajtimi

Diagnostic Test: Subjective accomodation amplitude measurement

Faza

Grupet e krahëve

Krah	Ndërhyrja / trajtimi
High AA group Group 1 consisted of those having an AA level of 3.57-4.16 D (high AA group; those who had near clear vision between 24-28 cm). .
Low AA group Group 2 consisted of those having an AA level of 3.44-3.03 D (low AA group; those who had near clear vision between 29-33 cm)

Kriteret e pranimit

Moshat e pranueshme për studim	49 Years Për të 49 Years
Gjinitë e pranueshme për studim	All
Metoda e marrjes së mostrës	Non-Probability Sample
Pranon Vullnetarë të Shëndetshëm	po
Kriteret	Inclusion Criteria: Healthy Volunteers, mean 50 years of age (49-51) Exclusion Criteria: Hypertension, Diabetes mellitus, Atrial fibrillation, Coronary artery disease, Arrhythmia, Hyperthyroidism , Anemia, Heart failure, Respiratory diseases, Severe obesity (body mass index ≥35 kg/m2),

Rezultati

Masat Kryesore të Rezultateve

1. ECG interval changes meauserements(ms,mm,number) [1 day]

ECG PR interval (ms),Ventricle Premature Systol(number),Left Ventricle Hypertrophy(mm)Right Bundle Branch,Left Bundle Branch (the presence / absence)

2. Holter implementation [1 day]

To detect autonomic cardiac aging based on heart rate variability (HRV),the low frequency (LF)/high frequency (HF) ratio was measured using a CardioScan II (version 11.4.0054a; DMS Software, Stateline, NV, USA)

3. Echocardiographic measurements [1 day]

Diastolic dysfunction meauserements(mitral anulus lateral e' velocity <10 cm/s, average E/e' ratio >14, Left atrium maximum volume index (LAv.i.) >34 mL/m2, and peak Tricuspit Regurgitation velocity >2.8 m/s.