Involvement of Nervous System in Muscle Weakness in COPD Patients
Fjalë kyçe
Abstrakt
Përshkrim
COPD is a common disease that induces many systemic repercussions. Among these, peripheral muscle dysfunction is particularly deleterious because it leads to the decreases of the level of activity and the quality of life for patients. Movement involves activation of many structures, from the instructor, i.e. the brain, to the effector, i.e. the muscle. Netherless, the studies which have described peripheral muscle dysfunction have been focused on the muscle, so they have proposed a reducing vision of the phenomenon. Other studies have reported cerebral alterations in COPD, like cognitive disturbance, increase of the neuronal conduction time, and decrease of the white matter density, and were associated with chronic hypoxemia. Such alterations are consistent with the existence of a decrease of the central motor drive during voluntary movement in COPD patients. Therefore the study will aim to determine precisely which mechanisms are involved in peripheral muscle dysfunction in copd.
Datat
Verifikuar së fundmi: | 02/28/2015 |
Paraqitur së pari: | 09/02/2012 |
Regjistrimi i vlerësuar u dorëzua: | 09/02/2012 |
Postuar së pari: | 09/05/2012 |
Përditësimi i fundit i paraqitur: | 03/08/2015 |
Përditësimi i fundit i postuar: | 03/09/2015 |
Data e fillimit të studimit aktual: | 06/30/2012 |
Data e vlerësuar e përfundimit primar: | 03/31/2014 |
Data e vlerësimit të përfundimit të studimit: | 03/31/2014 |
Gjendja ose sëmundja
Faza
Grupet e krahëve
Krah | Ndërhyrja / trajtimi |
---|---|
COPD nocturnal desaturator COPD patients who spend 30% of the nigth with a SaO2 < 90%. | |
COPD no nocturnal desaturator COPD patients who spend less than 30% of the night with a SaO2 < 90% | |
control group healthy sedentary subjects |
Kriteret e pranimit
Moshat e pranueshme për studim | 40 Years Për të 40 Years |
Gjinitë e pranueshme për studim | All |
Metoda e marrjes së mostrës | Non-Probability Sample |
Pranon Vullnetarë të Shëndetshëm | po |
Kriteret | Inclusion Criteria: - COPD Patients at stage 2 and 3 - Healthy sedentary subjects Exclusion Criteria: - Epilepsy, pace-maker, nervous disorders |
Rezultati
Masat Kryesore të Rezultateve
1. Level of voluntary activation [2h]