Retinol on Human Skin Aging in East Asian Descent
Fjalë kyçe
Abstrakt
Datat
Verifikuar së fundmi: | 02/28/2019 |
Paraqitur së pari: | 02/25/2016 |
Regjistrimi i vlerësuar u dorëzua: | 09/13/2016 |
Postuar së pari: | 09/19/2016 |
Përditësimi i fundit i paraqitur: | 03/24/2019 |
Përditësimi i fundit i postuar: | 04/15/2019 |
Data e paraqitjes së rezultateve të para: | 02/26/2019 |
Data e paraqitjes së parë të rezultateve të QC: | 03/24/2019 |
Data e rezultateve të para të postuara: | 04/15/2019 |
Data e fillimit të studimit aktual: | 10/31/2015 |
Data e vlerësuar e përfundimit primar: | 03/08/2018 |
Data e vlerësimit të përfundimit të studimit: | 03/08/2018 |
Gjendja ose sëmundja
Ndërhyrja / trajtimi
Drug: Older Group Ages 55-75
Drug: Older Group Ages 55-75
Faza
Grupet e krahëve
Krah | Ndërhyrja / trajtimi |
---|---|
Other: Older Group Ages 55-75 Active and Placebo. Participants received retinol lotion on one arm and placebo to match on the other arm. | Drug: Older Group Ages 55-75 Retinol in the form of vitamin A lotion |
No Intervention: Young Group Ages 18-25 Participants in the group will give tissue sample only for comparison. |
Kriteret e pranimit
Moshat e pranueshme për studim | 18 Years Për të 18 Years |
Gjinitë e pranueshme për studim | Female |
Pranon Vullnetarë të Shëndetshëm | po |
Kriteret | Inclusion Criteria: - able to provide written informed consent - older group: age between 50 and 75 years - young group: age 18 to 25 years - all four grandparents of Han Chinese, Japanese, Korean descent - body mass index within normal or overweight range - no history of weight loss of >20 lbs within past 5 years Exclusion Criteria: - skin condition in the areas of skin biopsy that would obscure results of analysis - topical creams or treatment to arms 2 weeks prior to study baseline visit - individuals with known hypersensitivity to retinoid class of agents (older group only) - prior anti-aging treatments to arms including retinol, microdermabrasion within 2 weeks of baseline visit - prior laser therapy or surgical procedure to arms - prior radiation or other trauma (extensive burns or abrasions) to arm skin - hormone-based therapy within 4 weeks of enrollment |
Rezultati
Masat Kryesore të Rezultateve
1. Number of Genes Upregulated or Downregulated as Assessed by RNA Sequencing (Older Group, Retinol Versus Placebo) [Week 12]
2. Number of Genes Upregulated or Downregulated as Assessed by RNA Sequencing (Younger Group Versus Older Group as Baseline) [Week 1]
Masat dytësore të rezultateve
1. Transepidermal Water Loss [Baseline; Week 12]
2. Severity of Arm Skin Wrinkling [Baseline; Week 12]
3. Elasticity on Arm Skin [Baseline; week 12]
4. Count of Participants With Skin and Subcutaneous Adverse Events as a Measure of Type and Severity of Adverse Events [Baseline through week 12]