Studies of White Blood Cells Derived From HHT Patients
Vetëm përdoruesit e regjistruar mund të përkthejnë artikuj
Identifikohuni Regjistrohu
Lidhja ruhet në kujtesën e fragmenteve
StatusiAktive, jo rekrutuese
Sponsorët
Imperial College London
Bashkëpunëtorë
British Heart Foundation
TRAJTIM KLINIKAL: NCT00230633
BioSeek: nct00230633
Fjalë kyçe
Abstrakt
Hereditary Haemorrhagic Telangiectasia (HHT, also known as Osler-Weber-Rendu Syndrome) is an disease that leads to the development of dilated and fragile blood vessels. We propose to take blood samples from patients with HHT, and culture white blood cells that express the proteins mutated in HHT, namely endoglin and ALK-1. We will study the properties of these cells which will involve their growth in media prompting different types of differentiation, or infection of cell lines with Epstein Barr virus to provide cell lines which can be repeatedly studied. It is anticipated that DNA, mRNA and proteins will be extracted from these cells for study of white cell responses and association with expression levels of endoglin and ALK-1 We hypothesize that these cells which express "half-normal" endoglin or ALK-1 will show altered protein synthetic differences when compared to normal white blood cells. We anticipate that that these findings may help to explain aspects of the HHT disease phenotype.
Datat
Verifikuar së fundmi: | 09/30/2019 |
Paraqitur së pari: | 09/28/2005 |
Regjistrimi i vlerësuar u dorëzua: | 09/28/2005 |
Postuar së pari: | 10/02/2005 |
Përditësimi i fundit i paraqitur: | 10/06/2019 |
Përditësimi i fundit i postuar: | 10/08/2019 |
Data e fillimit të studimit aktual: | 03/31/2002 |
Data e vlerësuar e përfundimit primar: | 09/30/2026 |
Data e vlerësimit të përfundimit të studimit: | 09/30/2026 |
Gjendja ose sëmundja
Telangiectasia, Hereditary Hemorrhagic
Faza
-
Kriteret e pranimit
Gjinitë e pranueshme për studim | All |
Metoda e marrjes së mostrës | Non-Probability Sample |
Pranon Vullnetarë të Shëndetshëm | po |
Kriteret | Inclusion Criteria: - Patients with HHT, - HHT patients family members Exclusion Criteria: - Unable to provide informed consent |
Rezultati
Masat Kryesore të Rezultateve
1. Proteins and cellular markers related to coagulation [on average completing in 1-5 years]
Not specified at outset. Blood samples will be collected over the recruitment period, usually on a single day. Analyses of biomarkers relate to the SAME DAY, within 24hs, though will be evaluated over subsequent months, on average completing in 1-5 years.