The Effects of Nicotine Chewing Gum in Parkinson's Disease

Vetëm përdoruesit e regjistruar mund të përkthejnë artikuj

Identifikohuni Regjistrohu

Lidhja ruhet në kujtesën e fragmenteve

StatusiPërfunduar

Sponsorët

New York Institute of Technology

TRAJTIM KLINIKAL: NCT02452125

BioSeek: nct02452125

Fjalë kyçe

Abstrakt

The objective of this experiment is:

To determine if nicotine chewing gum will improve acute episodes of orthostatic hypotension in PD subjects.

Përshkrim

Subjects will be asked to sit and rest for 10 minutes. Blood pressure will be taken in this resting position after the 10 minutes.

After all inclusion criteria has been met, subjects will then wear an automated BP cuff and be administered 4mg of nicotine gum (Nicorette™). They will be instructed to use it according to manufacturer's directions and remain chewing the gum for 30 minutes. The subject will remain in a seated position and BP and HR will be recorded every 5 minutes for 30 minutes. After 30 minutes the gum will be removed and subjects will still have HR and BP monitored in the seated position for another hour every 10 minutes. All values will be compared to pretreatment values. After 120 minutes if the subject is non-symptomatic, they can go home.

Datat

Verifikuar së fundmi:	06/30/2017
Paraqitur së pari:	05/19/2015
Regjistrimi i vlerësuar u dorëzua:	05/20/2015
Postuar së pari:	05/21/2015
Përditësimi i fundit i paraqitur:	07/24/2017
Përditësimi i fundit i postuar:	07/27/2017
Data e fillimit të studimit aktual:	04/30/2015
Data e vlerësuar e përfundimit primar:	05/31/2017
Data e vlerësimit të përfundimit të studimit:	05/31/2017

Gjendja ose sëmundja

Low Blood Pressure

Parkinsons Disease

Ndërhyrja / trajtimi

Dietary Supplement: Nicotine Gum

Faza

Grupet e krahëve

Krah	Ndërhyrja / trajtimi
Experimental: Nicotine Gum Nicotine chewing gum administered for 30 minutes	Dietary Supplement: Nicotine Gum Nicotine chewing gum

Kriteret e pranimit

Gjinitë e pranueshme për studim

All

Pranon Vullnetarë të Shëndetshëm

Kriteret

Inclusion Criteria:

- a diagnosis of PD

- a diastolic BP less than 90 mmHg

- and/or a systolic BP lower than 100mHg.

Exclusion Criteria:

- current tobacco users in all forms of tobacco

- severe dysphasia (difficulty swallowing)

- previous tobacco users who might be at risk for re-addiction.

Rezultati

Masat Kryesore të Rezultateve

1. Blood Pressure [90 minutes]

Masat dytësore të rezultateve

1. Heart Rate [90 Minutes]