Zinc Bioavailability From Amaranth-enriched Maize Tortillas

Vetëm përdoruesit e regjistruar mund të përkthejnë artikuj

Identifikohuni Regjistrohu

Lidhja ruhet në kujtesën e fragmenteve

StatusiPërfunduar

Sponsorët

University of Colorado, Denver

Bashkëpunëtorë

International Atomic Energy Agency

Universidad Francisco Marroquín

TRAJTIM KLINIKAL: NCT02208609

BioSeek: nct02208609

Fjalë kyçe

Abstrakt

Young children in Guatemala are at risk for nutrient deficiencies due to plant-based diets and poor sanitation. Stunting, frequent diarrhea, and respiratory infections are common. Supplementation of Zn to children during diarrhea episodes has been shown to diminish duration and severity of illness. Poor Zn absorption due to high fiber and phytate in this diet might play a role in these processes. Supplementation of this micronutrient in the diet might be beneficial. The investigators will compare absorption of Zn from white maize tortillas enriched with 20% amaranth to traditional white corn tortillas in preschool children in Guatemala.

Përshkrim

This is a randomized cross-over study of zinc absorption in young children living in the Western Highlands of Guatemala. Absorption of zinc will be measured from maize tortillas and maize tortillas fortified with 20% amaranth as the major food staple which provides at least 70% energy and at least 90% zinc and phytate of the diet. Participants will be randomized as to which type of tortilla they receive on the first and second day. Fractional absorption of zinc (FAZ) from all meals in one day for one type of tortilla and one day for the other will be measured by extrinsic labeling with stable isotopes of zinc. FAZ will be measured by a dual isotope tracer ratio (DITR) technique based on ratio of urine enrichment of orally versus intravenously administered zinc stable isotopes. Measurement of total zinc in duplicate diets on test days allow for determination of quantities of this micronutrient absorbed.

Datat

Verifikuar së fundmi:	03/31/2016
Paraqitur së pari:	07/31/2014
Regjistrimi i vlerësuar u dorëzua:	08/03/2014
Postuar së pari:	08/04/2014
Përditësimi i fundit i paraqitur:	04/26/2016
Përditësimi i fundit i postuar:	04/28/2016
Data e fillimit të studimit aktual:	12/31/2011
Data e vlerësuar e përfundimit primar:	11/30/2015
Data e vlerësimit të përfundimit të studimit:	11/30/2015

Gjendja ose sëmundja

Nutritional Deficiency

Ndërhyrja / trajtimi

Other: Maize Tortillas with 20% Amaranth

Other: Maize Tortillas without 20% Amaranth

Faza

Grupet e krahëve

Krah	Ndërhyrja / trajtimi
Experimental: Maize Tortillas with 20% Amaranth Children in this arm were fed maize tortillas fortified with 20% amaranth	Other: Maize Tortillas with 20% Amaranth Subjects received Maize tortillas with 20% Amaranth added.
Experimental: Maize Tortillas without 20% Amaranth Children in this arm were fed maize tortillas without amaranth	Other: Maize Tortillas without 20% Amaranth Maize tortillas without Amaranth.

Kriteret e pranimit

Moshat e pranueshme për studim	18 Months Për të 18 Months
Gjinitë e pranueshme për studim	All
Pranon Vullnetarë të Shëndetshëm	po
Kriteret	Inclusion Criteria: - 2-3 years of age - apparently healthy - eats >2-3 tortillas at each meal of the day. Exclusion Criteria: - Chispitas or macrovital supplementation - breastfeeding - birth weight < 2,500 g - birth defect affecting growth and development - chronic infection - twin or triplet - sibling enrolled in study

Rezultati

Masat Kryesore të Rezultateve

1. Zinc Absorption [2 days]

Absorption of zinc will be compared in young children when fed the common maize tortilla and a tortilla fortified with 20 % amaranth.. Fractional absorption of zinc for a day will be measured by extrinsic labeling with stable isotopes of zinc. Fractional absorption of zinc will be measured by a dual isotope tracer ratio technique. Measurement of total zinc in duplicate diets on test day will allow determination of quantity of this micronutrient absorbed (mg/d).