Contribution of common genetic variants to antidepressant response.
Fjalë kyçe
Abstrakt
BACKGROUND
Pharmacogenetic studies aiming to personalize the treatment of depression are based on the assumption that response to antidepressants is a heritable trait, but there is no compelling evidence to support this.
METHODS
We estimate the contribution of common genetic variation to antidepressant response with Genome-Wide Complex Trait Analysis in a combined sample of 2799 antidepressant-treated subjects with major depressive disorder and genome-wide genotype data.
RESULTS
We find that common genetic variants explain 42% (SE = .180, p = .009) of individual differences in antidepressant response.
CONCLUSIONS
These results suggest that response to antidepressants is a complex trait with substantial contribution from a large number of common genetic variants of small effect.
