Intravitreal methotrexate resistance in a patient with primary intraocular lymphoma.
Fjalë kyçe
Abstrakt
OBJECTIVE
To describe the clinical course of a patient with multiple recurrences of primary intraocular lymphoma (PIOL).
METHODS
Interventional case report,
METHODS
Retrospective chart review.
RESULTS
A 57-year-old female treated with multiple intravitreal methotrexate injections became refractory to intravitreal methotrexate after a year. Lymphoma cells evaluated using immunocytochemistry and confocal microscopy showed aberrant multidrug resistance-related protein (MRP) and decreased reduced folate carrier (RFC) and folate binding protein (FBP) expression compared to PIOL cells from another patient clinically responsive to methotrexate.
CONCLUSIONS
This case suggests that alterations in the transport of methotrexate across the cell membrane might contribute to resistance following repeated intravitreal injections.
