Organic Letters 2012-Apr
Isoleucine-catalyzed direct asymmetric aldol addition of enolizable aldehydes.
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Abstrakt
Isoleucine-catalyzed direct enantioselective aldol additions between enolizable aldehydes are reported. Intermediate acetal structures dictate the configurative outcome and were supported by a hydrogen bond. This direct isoleucine-catalyzed aldol addition represents a welcome complement to both proline- and histidine-catalyzed aldol additions of enolizable aldehydes.
