[Studies on the synthesis of dl-ligustiphenol and its analogues].
Fjalë kyçe
Abstrakt
S-( -- )-Ligustiphenol is a new sesquiterpene with anti-inflammatory and immunosuppressive activities. In order to study its pharmacological activities, the total synthesis of its racemat was carried out by a six-step reaction sequence including bromination of aldehyde, iodination of m - cresol, protection of phenolic hydroxyl, Grignard reaction, Aldol condensation, etc. The target compound was characterized by comparing its 1(H)-NMR, MS and IR spectra with natural ( -- )-ligustiphenol. In order to study the structure-activity relationships of ligustiphenol, it five analogues were designed and synthesized. The pharmacological screening of these analogues has been performed.