[Advancement of E2F1 in Common Tumors]
Fjalë kyçe
Abstrakt
The cell cycle-related transcription factor E2F1 is a member of the cell cycle-related transcription factor E2F family, mainly involved in various cell processes including cell cycle progression, DNA repair, DNA replication, cell differentiation, proliferation, and apoptosis. E2F1 is highly expressed in a variety of tumor tissues and cells, and it plays a role as a cancer-promoting gene. The up-regulation of E2F1 expression is closely related to the occurrence, development, metastasis and prognosis of tumors. Therefore, E2F1 is expected to become a new target for cancer treatment. This article reviews the latest research progress of E2F1 in current common tumors. .
【中文题目：E2F1在常见肿瘤中的最新研究进展】 【中文摘要：细胞周期相关转录因子E2F1（E2F transcription factor 1）是细胞周期相关转录因子E2F家族成员之一，主要参与包括细胞周期进展、DNA修复、DNA复制、细胞分化，增殖和凋亡等多种细胞过程。E2F1在全身多种肿瘤组织和细胞中呈高表达，起着促癌基因的作用，E2F1表达上调与肿瘤的发生、发展、转移及预后密切相关。因此，E2F1有望成为肿瘤治疗的新靶点。本文就E2F1在目前常见肿瘤中的最新研究进展做一综述。 】 【中文关键词：E2F1；肿瘤；细胞周期相关转录因子】.
Keywords: Cell cycle-related transcription factor; E2F1; Tumor.
