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Pharmacy research at URI: mining red maple (Acer rubrum) trees for novel therapeutics to manage diabetes.

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In vitro and in vivo anti-inflammatory effects of ethanol extract from Acer tegmentosum.

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OBJECTIVE Acer tegmentosum has been traditionally used for folk medicine to treat hepatic disorders such as hepatitis, hepatic cancer, and hepatic cirrhosis. In this study, we demonstrate the ethno-pharmacological activity of Acer tegmentosum in in vitro and in vivo inflammatory

Red maple (Acer rubrum) leaf toxicosis in horses: a retrospective study of 32 cases.

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BACKGROUND Ingestion of wilted red maple leaves by horses can result in severe hemolytic anemia and methemoglobinemia. Little is known about what factors influence the outcome of red maple leaf toxicosis in horses. OBJECTIVE Our hypothesis was that physical examination findings, clinicopathologic

Effect of Acer tegmentosum bark on atopic dermatitis-like skin lesions in NC/Nga mice.

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BACKGROUND Atopic dermatitis (AD) is a chronic and relapsing inflammatory condition characterized by pruritic and eczematous skin lesions that requires safe and effective pharmacological therapy. The bark of Acer tegmentosum Maxim trees has been used in Korean folk and traditional medicine to treat

Acer okamotoanum Nakai Leaf Extract Inhibits Adipogenesis Via Suppressing Expression of PPAR γ and C/EBP α in 3T3-L1 Cells.

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The genus Acer contains several species with various bioactivities including antioxidant, antitumor and anti-inflammatory properties. However, Acer okamotoanum Nakai, one species within this genus has not been fully studied yet. Therefore, in this study, we investigated the anti-adipogenic

Antifungal activity of plant extracts against Arthrinium sacchari and Chaetomium funicola.

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Various plant extracts were examined for antifungal activity with the objective of improving the commercial sterility of aseptically filled tea beverage products in PET bottles. When the hot water extract and the methanol extract of 29 samples were measured for their antifungal activity against

Effects of two fungicide formulations on microbial and macroinvertebrate leaf decomposition under laboratory conditions.

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Aquatic fungi contribute significantly to the decomposition of leaves in streams, a key ecosystem service. Little is known, however, about the effects of fungicides on aquatic fungi and macroinvertebrates involved with leaf decomposition. Red maple (Acer rubrum) leaves were conditioned in a stream

Collophora aceris, a novel antimycotic producing endophyte associated with Douglas Maple.

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A novel endophyte designated Collophora aceris, was obtained from stem tissues of Douglas Maple (Acer glabrum var. douglasii) in a Pacific Northwest temperate rainforest. Colonies were slow growing, white, creamy, moist, and translucent to opaque on potato dextrose agar and other media with few

An economic comparison of chloroquine and sulfadoxine-pyrimethamine as first-line treatment for malaria in South Africa: development of a model for estimating recurrent direct costs.

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The relative cost-effectiveness of chloroquine (CQ) and sulfadoxine-pyrimethamine (SP) as first-line antimalarial therapy in southern Africa is of great interest to policymakers, clinicians and researchers in the subregion. A model was developed to access the cost-effectiveness of replacing CQ with

Identification of Maple Anthocyanin and Its Antiproliferative Activity against LLC, T47D and C3H10T1/2 Cells

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Background: The genus Acer contains around 200 species, with more than 400 garden varieties. There is considerable diversity in these species and garden varieties, and each can be characterized by morphology and chemical composition. The

Base cation stimulation of mycorrhization and photosynthesis of sugar maple on acid soils are coupled by foliar nutrient dynamics.

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The nutritional benefits that mycorrhizal associations provide to plants may be constrained by acidic soil conditions resulting in decreased photosynthetic function. Sugar maple (Acer saccharum) and red maple (Acer rubrum) seedlings were grown on a native acidic (pH 4.1) soil both unamended and

Pollen allergenic potential nature of some trees species: a multidisciplinary approach using aerobiological, immunochemical and hospital admissions data.

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Trees are considered producers of allergenic pollen. The aims of this work were to characterize the aerobiology of the Platanus, Acer, Salix, Quercus, Betula and Populus pollen, linking it with monthly emergency hospital admissions and to identify the different reactivity levels in sensitized

Clinical outcomes and cost-effectiveness of primary treatment of ovarian cancer in North-Western Romania.

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Ovarian cancer has the poorest survival rate among gynaecological malignancies. Besides the comparison of different therapeutic strategies aimed to improve outcomes, studies have also begun to focus on aspects of cost-effectiveness of these strategies. In this context, we proposed to

An old drug for a rare disease: The example of celiprolol for vascular Ehlers-Danlos syndrome.

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Vascular Ehlers-Danlos syndrome (OMIM 130050, 1/150,000 birth) is caused by mutations in collagen 3A1 gene. It is associated with severe phenotype associating early arterial dissection and rupture, digestive and uterine perforations, and skin and joints fragility. Until recently, no treatment was

Suppression of 6-Hydroxydopamine-Induced Oxidative Stress by Hyperoside Via Activation of Nrf2/HO-1 Signaling in Dopaminergic Neurons.

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In our ongoing research to discover natural products with neuroprotective effects, hyperoside (quercetin 3-O-galactoside) was isolated from Acer tegmentosum, which has been used in Korean traditional medicine to treat liver-related disorders. Here, we demonstrated that hyperoside protects cultured

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