Most angiosperms encode a small family of 4-coumarate:CoA-ligases (4CLs) activating hydroxycinnamic acids for lignin and flavonoid pathways. The common rue, Ruta graveolens L., additionally produces coumarins by cyclization of the 4-coumaroyl moiety, possibly involving the CoA-ester, as well as
The floxacrine derivative S 82 5455, 7-chloro-1-( 4N - methylpiperazino -1N-imino)-10-hydroxy-1, 2, 3, 4-tetrahydro-3-(4-trifluoromethylphenyl)-9(10 H)- acridone , shows a high activity against blood induced infection of a drug-sensitive line of Plasmodium berghei in mice and rats. The dosis