angiomyolipoma/hypoxia

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Activation of the ER stress and calcium signaling in angiomyolipoma.

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Identifikohuni Regjistrohu

Renal angiomyolipomas (AMLs) are uncommon benign tumors that occur sporadically or as a part of tuberous sclerosis complex (TSC). Risk of life threatening hemorrhage is the main clinical concern. Although several evidences suggest that hyper-activation of the mammalian target of rapamycin complex 1

Selective arterial embolization of angiomyolipoma leading to pulmonary hypertension.

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Identifikohuni Regjistrohu

OBJECTIVE To report two cases of secondary pulmonary hypertension resulting from microsphere extravasation following selective arterial embolization of renal angiomyolipoma, its diagnosis, and management. METHODS We reviewed the cases of two patients at the University of California, San Francisco,

[Lymphangioleiomyomatosis].

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Identifikohuni Regjistrohu

Lymphangioleiomyomatosis is a rare pulmonary disease encountered almost exclusively in women of reproductive age. Pulmonary involvement is characterized by multiple thin-walled cysts in the lungs, recurrent pneumothorax, obstructive lung disorders, and progression to chronic respiratory failure over

EPIDEMIOLOGY, PATHOGENESIS and DIAGNOSIS of LYMPHANGIOLEIOMYOMATOSIS.

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Identifikohuni Regjistrohu

BACKGROUND Lymphangioleiomyomatosis (LAM) is a disease of women characterized by cystic lung destruction, lymphatic involvement, and renal angiomyolipomas. UNASSIGNED LAM is caused by proliferation of abnormal smooth muscle-like LAM cells containing mutations and perhaps epigenetic modifications of

[Pulmonary involvement of Bourneville's tuberous sclerosis. The value of early detection. A familial form].

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Identifikohuni Regjistrohu

Pulmonary disease is very rare during the course of tuberous sclerosis of Bourneville (STB). The authors report two cases of STB with pulmonary involvement occurring in the same family, mother and daughter. Both presented with typical cutaneous manifestations of the disease and bilateral renal

Clinical features, epidemiology, and therapy of lymphangioleiomyomatosis.

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Identifikohuni Regjistrohu

Lymphangioleiomyomatosis (LAM) is a multisystem disease of women, characterized by proliferation of abnormal smooth muscle-like LAM cells, leading to the formation of lung cysts, fluid-filled cystic structures in the axial lymphatics (eg, lymphangioleiomyomas), and renal angiomyolipomas. LAM is

Clinical and molecular insights into lymphangioleiomyomatosis.

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Identifikohuni Regjistrohu

Lymphangioleiomyomatosis (LAM) is a rare disease of women that is characterized by a proliferation of abnormal smooth muscle-like cells (LAM cells), which leads to cystic lung lesions, lymphatic abnormalities, and abdominal tumors (e.g., angiomyolipomas). LAM occurs sporadically or in association

The natural history of lymphangioleiomyomatosis: markers of severity, rate of progression and prognosis.

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Identifikohuni Regjistrohu

Lymphangioleiomyomatosis (LAM) is a multisystem disease of women, characterized by proliferation of abnormal smooth muscle-like cells (LAM cells) that can metastasize, leading to the formation of lung cysts, fluid-filled cystic structures in the axial lymphatics (e.g., lymphangioleiomyomas), and

TSC2 deficiency increases PTEN via HIF1alpha.

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Identifikohuni Regjistrohu

Substantial evidence suggests roles of TSC2 and PTEN in the development of cancer predisposition syndromes. Loss of TSC2 results in benign tumors, neurological disorders, and angiomyolipomas. We found that PTEN mRNA and protein levels are elevated in Tsc2(-/-) mouse embryo fibroblasts with

Hand-assisted laparoscopic partial nephrectomy after 60 cases: comparison with open partial nephrectomy.

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Identifikohuni Regjistrohu

BACKGROUND Partial nephrectomy is the surgical standard of care for favorably located, small renal tumors. As the incidence of renal cell carcinoma (RCC) and detection of small kidney masses have increased over the past 20 years, minimally invasive management of these lesions has become more common.

Lymphangioleiomyomatosis.

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Identifikohuni Regjistrohu

BACKGROUND Lymphangioleiomyomatosis (LAM) is a rare disease that is characterized by proliferation of abnormal smooth muscle-like cells (LAM cells), which leads to the formation of lung cysts, fluid-filled cystic structures in the axial lymphatics, and abdominal tumors. It primarily affects

Carbonic anhydrase IX expression in renal neoplasms: correlation with tumor type and grade.

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Identifikohuni Regjistrohu

Carbonic anhydrase IX (CAIX), a hypoxia-induced protein, is expressed in some renal tumors. We evaluated its immunohistochemical expression in 317 primary and 42 metastatic renal neoplasms (186 clear cell, 52 papillary, 35 chromophobe, 47 unclassified, and 15 Xp11.2 translocation renal cell

Comprehensive evaluation of 35 patients with lymphangioleiomyomatosis.

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Identifikohuni Regjistrohu

OBJECTIVE To evaluate comprehensively the characteristics of lymphangioleiomyomatosis (LAM), with emphasis on the application of imaging and immunohistochemical methods. METHODS Prospective study. METHODS Thirty-five female subjects with LAM. METHODS Clinical Center, National Institutes of

mTORC1 drives HIF-1α and VEGF-A signalling via multiple mechanisms involving 4E-BP1, S6K1 and STAT3.

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Identifikohuni Regjistrohu

Recent clinical trials using rapalogues in tuberous sclerosis complex show regression in volume of typically vascularised tumours including angiomyolipomas and subependymal giant cell astrocytomas. By blocking mechanistic/mammalian target of rapamycin complex 1 (mTORC1) signalling, rapalogue

The tuberous sclerosis complex regulates trafficking of glucose transporters and glucose uptake.

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Identifikohuni Regjistrohu

Human cancers often display an avidity for glucose, a feature that is exploited in clinical staging and response monitoring by using (18)F-fluoro-deoxyglucose (FDG) positron emission tomography. Determinants of FDG accumulation include tumor blood flow, glucose transport, and glycolytic rate, but

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