aotus/inflammation

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13 rezultatet

Structural and functional characterisation of the Toll like receptor 9 of Aotus nancymaae, a non-human primate model for malaria vaccine development.

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Identifikohuni Regjistrohu

In the absence of suitable rodent animal models for Plasmodium falciparum malaria, the efficacy testing of asexual blood-stage vaccine candidates in Aotus nancymaae represents a tool to select between different formulations before conducting expensive human clinical trials. CpG oligonucleotides

Plasmodium falciparum merozoite vaccination in Aotus monkeys recovered spontaneously from P. falciparum infection: a clinical study.

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Identifikohuni Regjistrohu

6 Aotus trivirgatus monkeys, which had all spontaneously recovered from an experimentally induced Plasmodium falciparum infection, were included in a clinical study concentrating on possible adverse reactions caused by a vaccine using late schizonts and merozoites as an antigen a synthetic compound,

Immunohistochemical detection of cytokines in tissues of Aotus monkeys infected with hepatitis A virus.

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Identifikohuni Regjistrohu

Cytokines IL-1-beta, IL-2, and TNF alpha were detected in occasional cells within portal inflammatory infiltrates beginning 3 weeks after oral inoculation of monkeys with HAV. The number of cells secreting those cytokines did not increase, and they were not of importance in the pathogenesis.

Antiviral activity of chloroquine against dengue virus type 2 replication in Aotus monkeys.

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Dengue virus (DENV) of the Flaviviridae family is a single positive-stranded RNA virus that is transmitted by Aedes aegypti and Aedes albopictus mosquitoes. The objective of this study was to investigate the use of chloroquine (CLQ) as an antiviral drug against dengue virus in monkeys. To analyze

Pathology of hepatitis A infection in the owl monkey (Aotus trivirgatus).

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Identifikohuni Regjistrohu

Sequential liver biopsies of owl monkeys that had been experimentally infected with one of two strains of hepatitis A virus (HM-175 or PA-33) were examined for histopathologic alterations. Preinoculation biopsies were normal with only occasional minimal mononuclear cell infiltrates in portal tracts

Experimental infection of the New World owl monkey (Aotus trivirgatus) with hepatitis A virus.

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Identifikohuni Regjistrohu

Epidemiological studies have demonstrated the susceptibility of the owl monkey (Aotus trivirgatus) to hepatitis A virus, but have not shown an association between infection and histopathological or chemical evidence of liver disease. Therefore, 12 seronegative, colony-bred monkeys were inoculated

Glomerulonephritis in the owl monkey (Aotus trivirgatus): ultrastructural observations.

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Identifikohuni Regjistrohu

The kidneys of 11 clinically healthy owl monkeys (Aotus trivirgatus) acquired from four different sources were examined by light and electron microscopy. Eight of the 11 animals had morphologic evidence of glomerulonephritis. The lesions were characterized by one or more of the following changes:

Evaluation of the Safety and Biodistribution of M032, an Attenuated HSV-1 Virus Expressing hIL-12, After Intracerebral Administration to Aotus Non-Human Primates.

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Identifikohuni Regjistrohu

Herpes simplex virus type 1 (HSV-1) mutants lacking the γ134.5 neurovirulence loci are promising agents for treating malignant glioma. Arming oncolytic HSV-1 (oHSV) to express immunostimulatory genes may potentiate therapeutic efficacy. We have previously demonstrated improved pre-clinical efficacy,

Experimental toxoplasmosis and vaccine tests in Aotus monkeys.

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Identifikohuni Regjistrohu

We studied Aotus lemurinus, Panamanian night monkeys, for susceptibility to Toxoplasma infection and for their capacity to develop immunity using either sufadiazine prophylaxis or the non-persistent ts-4 vaccine. The animals were highly susceptible to infection with a mouse pathogenic (T265) and a

Restasis for the treatment of 'dry eye' in Aotus nancymaae.

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Identifikohuni Regjistrohu

BACKGROUND This case report describes the treatment of three male owl monkeys (Aotus nancymaae) diagnosed with chronic dry eye with a topical cyclosporine product, Restasis, approved for use in humans. These owl monkeys had ocular disease resulting from procedures performed at a biotechnology

The owl monkey (Aotus trivirgatus) as an animal model in trachoma research.

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Identifikohuni Regjistrohu

The owl monkey, Aotus trivirgatus, in contrast to other species of nonhuman primates, was shown to be susceptable to infection with strains of Chlamydia trachomatis. It responded to experimental infection with a severe, acute, inflammatory reaction of short duration. Monkeys which recovered from

Susceptibility and lack of evidence for a viremic state of rabies in the night owl monkey, Aotus nancymaae.

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Identifikohuni Regjistrohu

BACKGROUND Rabies causes an acute fatal encephalomyelitis in most mammals following infection with rhabdovirus of the genus Lyssavirus. Little is known about rabies virus infection in species of New World non-human Primates (NHP). To investigate the suitability of the owl monkey Aotus nancymaae

Evaluation of the safety and biodistribution of M032, an attenuated herpes simplex virus type 1 expressing hIL-12, after intracerebral administration to aotus nonhuman primates.

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Identifikohuni Regjistrohu

Herpes simplex virus type 1 (HSV-1) mutants lacking the γ(1)34.5 neurovirulence loci are promising agents for treating malignant glioma. Arming oncolytic HSV-1 to express immunostimulatory genes may potentiate therapeutic efficacy. We have previously demonstrated improved preclinical efficacy,

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