artemisinin/inflammation

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[Anti-inflammatory effect and mechanism of artemisinin and dihydroartemisinin].

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Identifikohuni Regjistrohu

OBJECTIVE To study and compare the anti-inflammatory effect and molecular mechanism of artemisinin and dihydroartemisinin. METHODS Mouse mononuclear macrophage RAW264.7 cells were stimulated to release inflammatory mediators such as TNF-alpha, IL-6 and NO, in order to assess the drugs' inhibitory

Induction of apoptosis by artemisinin relieving the severity of inflammation in caerulein-induced acute pancreatitis.

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Identifikohuni Regjistrohu

OBJECTIVE To observe the apoptosis and oncosis of pancreatic acinar cells and secondary inflammatory reaction in pancreatic tissue from rats with acute pancreatitis (AP), and the influences of artemisinin on them. METHODS AP was induced by 4 intraperitoneal injections of caerulein at 1 h intervals.

Anti-inflammatory and immunomodulatory mechanisms of artemisinin on contact hypersensitivity.

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Identifikohuni Regjistrohu

Artemisinin (Art) is a sesquiterpene trioxane lactone from Artemisia annua L., which has been shown to affect immune responses. However, the underlying mechanism remains elusive. In this study, we examined the anti-inflammatory and immunomodulatory effects of Art in a mouse model of contact

The antinociceptive effect of artemisinin on the inflammatory pain and role of GABAergic and opioidergic systems.

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Identifikohuni Regjistrohu

Pain is a complex mechanism which involves different systems, including the opioidergic and GABAergic systems. Due to the side effects of chemical analgesic agents, attention toward natural agents have been increased. Artemisinin is an herbal compound with widespread modern and

Artemisinin alleviates atherosclerotic lesion by reducing macrophage inflammation via regulation of AMPK/NF-κB/NLRP3 inflammasomes pathway.

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Identifikohuni Regjistrohu

There is increasing evidence that atherosclerosis is the significant risk factor for cardiovascular diseases, which are the leading causes of morbidity and mortality worldwide. Artemisinin is a natural endoperoxides quiterpene lactone compound in Artemisia annua L with vasculoprotective effects. The

Anti-inflammatory properties and regulatory mechanism of a novel derivative of artemisinin in experimental autoimmune encephalomyelitis.

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Identifikohuni Regjistrohu

Ethyl 2-[4-(12-beta-artemisininoxy)]phenoxylpropionate (SM933) is a novel derivative of artemisinin, an herbal compound approved for the treatment of malaria. In this study, we show that SM933 has unique anti-inflammatory properties through regulation of signaling pathways, leading to amelioration

Artemisinin inhibits the proliferation, migration, and inflammatory reaction induced by tumor necrosis factor-α in vascular smooth muscle cells through nuclear factor kappa B pathway.

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Identifikohuni Regjistrohu

BACKGROUND Atherosclerosis is an inflammatory disease with the most common pathologic process leading to cardiovascular diseases. The aim of this study was to evaluate the effect of artemisinin (ART) on the proliferation, migration, and inflammation induced by tumor necrosis factor-α (TNF-α) of rat

Artemisinin suppresses sympathetic hyperinnervation following myocardial infarction via anti-inflammatory effects.

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Identifikohuni Regjistrohu

Inflammation plays an important role in sympathetic remodeling after myocardial infarction (MI), and the inhibition of inflammation has therapeutic benefits that could alleviate the progression of sympathetic remodeling. Recent studies have indicated that the antimalarial agent artemisinin has the

Artemisinin and Artemisia annua leaves alleviate Eimeria tenella infection by facilitating apoptosis of host cells and suppressing inflammatory response.

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Identifikohuni Regjistrohu

Evasion strategies of intracellular parasites by hijacking cellular pathways, are necessary to ensure successful survival and replication. Eimeria tenella (E. tenella) has the ability to circumvent apoptosis of infected cells through increased expression of the transcriptional factor NF-κB and the

Identification of HSP90 as a direct target of artemisinin for its anti-inflammatory activity via quantitative chemical proteomics.

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Identifikohuni Regjistrohu

The anti-malarial drug artemisinin (ART) possesses potent anti-inflammatory activity, yet its underlying mechanism of action has remained elusive. Here we employed quantitative chemical proteomics to in situ profile the cellular targets of ART and identified heat shock protein 90 (HSP90) as a direct

Artemisinin inhibits inflammatory response via regulating NF-κB and MAPK signaling pathways.

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Identifikohuni Regjistrohu

Artemisinin, isolated from the Chinese plant Artemisia annua, has been used for many years to treat different forms of malarial parasites. In this study, we explored the anti-inflammatory activity of artemisinin and the underlying mechanism of this action. We demonstrated that the anti-inflammatory

The new water-soluble artemisinin derivative SM905 ameliorates collagen-induced arthritis by suppression of inflammatory and Th17 responses.

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Identifikohuni Regjistrohu

OBJECTIVE Our previous study showed that SM905, a novel artemisinin derivative, exhibited potent immunosuppressive activity. In this study, we evaluate preventive and therapeutic effect of SM905 on collagen-induced arthritis (CIA) in DBA/1 mice, and investigate its mechanisms both in inflammatory

SM905, an artemisinin derivative, inhibited NO and pro-inflammatory cytokine production by suppressing MAPK and NF-kappaB pathways in RAW 264.7 macrophages.

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Identifikohuni Regjistrohu

OBJECTIVE To elucidate the anti-inflammatory potentials and underlying mechanisms of SM905, a novel artemisinin derivative, in lipopolysaccharide (LPS)-stimulated murine macrophage RAW 264.7 cells. METHODS Nitric oxide (NO) generation, cytokine production, and the protein expression levels of

Anti-inflammatory and immunoregulatory functions of artemisinin and its derivatives.

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Identifikohuni Regjistrohu

Artemisinin and its derivatives are widely used in the world as the first-line antimalarial drug. Recently, growing evidences reveal that artemisinin and its derivatives also possess potent anti-inflammatory and immunoregulatory properties. Meanwhile, researchers around the world are still exploring

Artemisinin, a potential option to inhibit inflammation and angiogenesis in rosacea.

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Identifikohuni Regjistrohu

Rosacea is a facial chronic inflammatory skin disease with dysfunction of immune and vascular system. Artemisinin (ART), an anti-malaria drug, was reported to have several effects including anti-inflammation and anti-angiogenesis activities. However, the role of ART on rosacea remains

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