artemisinin/seizures

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Cerebral Malaria Treated with Artemisinin in the Intensive Care Unit: A Case Report.

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Malaria is a parasitic disease that is starting to be encountered in intensive care units (ICU) worldwide, owing to increasing globalisation. Severe malaria caused by Plasmodium falciparum, is characterised by cerebral malaria, acute renal failure, hypoglycaemia, severe anaemia, splenomegaly and

Argemone mexicana decoction versus artesunate-amodiaquine for the management of malaria in Mali: policy and public-health implications.

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A classic way of delaying drug resistance is to use an alternative when possible. We tested the malaria treatment Argemone mexicana decoction (AM), a validated self-prepared traditional medicine made with one widely available plant and safe across wide dose variations. In an attempt to reflect the

Cerebral malaria: optimising management.

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Cerebral malaria is one of the most common nontraumatic encephalopathies in the world. Children living in sub-Saharan Africa bear the brunt of the disease, but cerebral malaria is being seen increasingly in adults throughout the world, including outside malarious areas. There are differences in the

Prescription pattern of antimalarial drugs in children below 5 years in a tertiary health institution in Nigeria.

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BACKGROUND This study examines the diagnosis of malaria and pattern of prescription of antimalarial drugs in the most vulnerable age group (the under 5 children) in the study environment in order to identify the possible shortcomings and suggest solutions so as to improve the treatment outcome in

Clinical malaria in the tropics.

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Although malaria has been largely eradicated from temperate countries, it is on the increase in the tropics. Infection with Plasmodium falciparum affects a vast number of people and kills over a million annually. Severe malaria is a multisystem disease affecting particularly the central nervous

Improving cognitive outcome in cerebral malaria: insights from clinical and experimental research.

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Cerebral Malaria (CM) is a clinical syndrome defined by the World Health Organization (WHO) as a potentially reversible diffuse encephalopathy characterized mainly by coma and the presence of asexual forms of Plasmodium falciparum parasites in peripheral blood smears in the absence of other causes

Pyronaridine-artesunate versus mefloquine plus artesunate for malaria.

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BACKGROUND Pyronaridine-artesunate is an artemisinin-based combination therapy under evaluation for the treatment of Plasmodium falciparum and P. vivax malaria. METHODS We conducted a phase 3, open-label, multicenter, noninferiority trial that included 1271 patients between 3 and 60 years of age

Investigating causal pathways in severe falciparum malaria: A pooled retrospective analysis of clinical studies.

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Severe falciparum malaria is a medical emergency characterised by potentially lethal vital organ dysfunction. Patient fatality rates even with parenteral artesunate treatment remain high. Despite considerable research into adjuvant therapies targeting organ and tissue dysfunction, none

Antiepileptic properties of Quinine: A systematic review.

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BACKGROUND Quinine has anti-epileptic properties in animals. However, in humans this has not been systematically investigated. OBJECTIVE To examine the available research evidence on the effects of quinine on seizures in adults or children. METHODS We searched online databases for published and

Factors influencing adherence to referral advice following pre-referral treatment with artesunate suppositories in children in rural Tanzania.

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OBJECTIVE WHO recommends artemisinin suppository formulations as pre-referral treatment for children who are unable to take oral medication and cannot rapidly reach a facility for parenteral treatment. We investigated factors influencing caretakers' adherence to referral advice following

UK malaria treatment guidelines 2016.

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1.Malaria is the tropical disease most commonly imported into the UK, with 1300-1800 cases reported each year, and 2-11 deaths. 2. Approximately three quarters of reported malaria cases in the UK are caused by Plasmodium falciparum, which is capable of invading a high proportion of red blood cells

General Pharmacology of Artesunate, a Commonly used Antimalarial Drug:Effects on Central Nervous, Cardiovascular, and Respiratory System.

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Artesunate, a semi-synthetic derivative of artemisinin, is used primarily as a treatment for malaria. Its effects on the central nervous system, general behavior, and cardiovascular, respiratory, and other organ systems were studied using mice, rats, guinea pigs, and dogs. Artesunate was

Antiepileptic properties of quinine: A systematic review.

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Identifikohuni Regjistrohu

UNASSIGNED Background: Quinine has been found to have anti-epileptic properties in animals. However, in humans this has not been systematically investigated. If quinine has antiepileptic properties in humans, it may reduce the neurological sequelae associated with acute seizures in severe malaria

Treatment of cerebral malaria and acute respiratory distress syndrome (ARDS) with parenteral artesunate.

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Identifikohuni Regjistrohu

Infection with Plasmodium Falciparum can cause a severe form of malaria with multiorgan involvement. Cerebrum is one of the organs involved in the P. Falciparum malaria, which can lead to coma, convulsions, and other neurological sequel. The sequestration of cerebral vasculature with parasitized red

[Assessment of the management of cases of fever and malaria by general practitioners in the central Highlands of Madagascar, 2009-2010].

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The aim of this study was to determine the frequency of confirmed malaria among patients with fever in the central Highlands of Madagascar, the clinical utility of treating this fever, and the involvement of community general practitioners in improving malaria management. This descriptive,

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