Fatigue

Ketamine

Midazolam

National Institutes of Health Clinical Center

A Proof-of-Concept Trial on the Effect of Ketamine on Fatigue

The primary outcome measure of the study is the percentage placebo change in self-reported fatigue VAS score before and 3 daysafter receiving ketamine or active placebo for each individual study participant. A 20% change in fatigue VAS score 3 days after ketamine treatment will be considered indication of efficacy in thisstudy.

cognition; skeletal muscle strength; motivation

change in gene expression or protein levels of pro inflammatory markers levels and bioenergetic markers

National Institute of Nursing Research (NINR)

Subjects will be given the virtual reality device to interact with prior to surgery without the use of a pre-medication.

Subjects will be given the drug Midazolam to help alleviate the pre-operative anxiety.

Tonsillectomy

Child will wear and interact with virtual reality headset while waiting for surgery.

Virtual Reality

Child will receive Midazolam to help with pre-operative anxiety prior to surgery

Phoenix Children's Hospital

Effects of Virtual Reality on Pre-Operative Anxiety and Induction of Anesthesia in Children and Adolescents

A Pilot Study to Evaluate the Efficacy of Virtual Reality on Pre-Operative Anxiety and Induction of Anesthesia in a Children's Hospital

Determine if the use of a VR device will result in lower mYPAS anxiety scores during the preoperative period

Determine if the use of a VR device will result in greater induction of anesthesia measured by the induction compliance checklist.

Determine if VR use will reduce incidence of post-operative emergence delirium measured by the PAED scale.

Measure if VR use will reduce post-operative pain scores compared to patients receiving standard of care.

Measure VR use will reduce opioid use compared to patients receiving standard of care

asthenopia/vomiting

A Proof-of-Concept Trial on the Effect of Ketamine on Fatigue

Effects of Virtual Reality on Pre-Operative Anxiety and Induction of Anesthesia in Children and Adolescents

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