Patients were given theta burst stimulation (intermittent TBS (iTBS) to the affected hemisphere and continuous TBS (cTBS) to the unaffected hemisphere) along with physiotherapy. TBS was delivered for 3 times in a week for 4 weeks.The stimulation was given with an intensity of 60% of RMT. The iTBS protocol of 10 bursts of high-frequency stimulation (3 pulses at 50 Hz) was applied at 5 Hz every 10 second for a total of 600 pulses.
Continuous TBS (inhibitory) was delivered to the unaffected hemisphere at the "hot-spot" with an intensity of 60% of RMT, 3 pulses at 50 Hz, repeated every 200 ms for a total of 600 pluses.

Patients in the functional electrical stimulation (FES) group received the electrical stimulation with electrodes positioned according to pattern 3 [Grasp/Flexion/Extension, PATT (pattern movement)] of the FES (F) mode of the instrument. The electrodes were connected to a stimulator controller unit that delivers alternating current at a frequency of 35 Hz and a pulse width of 200 µs, intensity 10~50 mA.
The FES group stimulation session was given for 30 minutes for each day 3 times in a week (alternate days) for 4 weeks and it was concurrently synchronized with the physiotherapy.

The following different physiotherapy regimens were followed for all the patients in the study.
Passive/Active Range of Motion (ROM); Weight bearing and supportive reaction; Reaching activities; Grasping, holding and release; Upper extremity activities of daily living (ADL). Physiotherapy intervention was given to all the patients 5 days per week for 1 month. In addition, all patients continued to receive in-home physiotherapy 1 to 2 times per week by a home physiotherapist who was guided by the research physiotherapist.

Strokes Thrombotic

Patients were given intermittent TBS to the affected hemisphere and continuous TBS to the unaffected hemisphere for 4 weeks along with physiotherapy.

Theta burst stimulation

Patients were given functional electrical stimulation of affected upper extremity for four weeks along with physiotherapy.

Functional Electrical Stimulation

Patients received active and passive physiotherapy of the affected extremity for four weeks.

Physiotherapy

Efficacy of the Theta Burst Stimulation and Functional Electrical Stimulation in Stroke Rehabilitation

Efficacy of the Theta Burst Stimulation and Functional Electrical Stimulation as Compared to Conventional Physiotherapy in Stroke Rehabilitation: A Randomized Controlled Trial

Fugl Meyer Assessment (FMA) scale, is designed to assess motor functioning, balance, sensation and joint functioning in patients with post-stroke hemiplegia. We used upper limb motor function domain of FMA scale which is a 66 point domain with a score ranging from 0-66. The lower score indicates more severe disability in upper limb motor functions.

Modified Rankin Scale (MRS) is a 7 point (0-6) ranking scale to assess neurological disability. A score of 0 indicates normal functions with no symptoms while higher scores indicates more severe neurological disability.

National Institute of Health Stroke Scale (NIHSS) is used to assess severity of impairment caused by stroke. It consists of 11 items with each item having a score of 0-4, where 4 indicates more severe disability. The score from all items is summed up to achieve the final NIHSS score. The score ranges from 0-44 where higher score indicates more severe impairment.

Annonymized individual participant data will be shared on request. Pl. contact: cbrathore@gmail.com.

Dr. Chaturbhuj Rathore

Associate Professor

Sree Chitra Tirunal Institute for Medical Sciences & Technology

Outcome assessor was blinded to the type of intervention.

norepinephrine 5mcg intravenously administered

phenylephrine 100mcg intravenously administered

Hypotension

bolus administered norepinephrine 5mcg intravenously, if SBP <90mmHg or 20% decrease from baseline

Norepinephrine

bolus administered phenylephrine 100mcg intravenously, if SBP <90mmHg or 20% decrease from baseline

Phenylephrine

Jeju National University Hospital

Norepinephrine and Phenylephrine for Maternal Cardiac Output During Spinal Anesthesia for Elective Cesarean Delivery

Norepinephrine and Phenylephrine for Cesarean Section

Change from Baseline at time 2, 3, 4, and 5

Ae ryoung Lee

Assistant Professor

The HSCT preparative regimen will consist of
Thymoglobulin: 2.5 mg /kg/day intravenously (IV) on Days -8 through -5
Fludarabine: 35 mg/m2/day IV on Days -8 through -4
Melphalan: 140 mg/m2 IV on Day -3
Rest on Day -2 and -1
Day 0 is the day of transplant
GVHD prophylaxis: sirolimus beginning on Day -1 for at least one year and mycophenolate mofetil (MMF) from Day -3 to +45 or to 7 days after neutrophil engraftment, whichever is later.

bola/stroke

Efficacy of the Theta Burst Stimulation and Functional Electrical Stimulation in Stroke Rehabilitation

Norepinephrine and Phenylephrine for Maternal Cardiac Output During Spinal Anesthesia for Elective Cesarean Delivery

HLA-Identical Sibling Donor Bone Marrow Transplantation for Individuals With Severe Sickle Cell Disease Using a Reduced Intensity Conditioning Regimen

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