dark/antikancer

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Anti-cancer activities of hypericin in the dark.

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Identifikohuni Regjistrohu

The potent photodynamic properties of hypericin (HY) elicit a range of light-dependent virucidal and tumoricidal activities. Yet, a relatively low reduction/oxidation potential endows HY with electron accepting and donating properties enabling it to act as both an oxidizing and a reducing agent. HY

Uncovering the dark side of TNF.

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Identifikohuni Regjistrohu

In the early 1980s, in search of the cytokine that triggers disease- associated weight loss and lethal shock, Anthony Cerami and Bruce Beutler purified "cachectin." They soon found out that their malevolent cytokine already had another name-tumor necrosis factor (TNF)-and was being lauded as a

A Dual Anticancer Efficacy Molecule: A Selective Dark Cytotoxicity Photosensitizer.

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Identifikohuni Regjistrohu

Unlike traditional binary nanostructures that construct chemotherapy drugs and photodynamic therapy photosensitizers, we introduce a molecule with a chemo-photodynamic dual therapy function. A water-soluble aggregation-induced emission enhancement (AIEE) fluorogen, NV-12P, was designed and

Tea and human health: the dark shadows.

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Identifikohuni Regjistrohu

Tea is one of the most popularly consumed beverage. Depending on the manufacturing process, different varieties of tea can be produced. The antioxidative and antimutagenic potential of tea in cardiovascular diseases, cancer and obesity have long been studied. These therapeutic and nutritional

The senescence-associated secretory phenotype: the dark side of tumor suppression.

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Identifikohuni Regjistrohu

Cellular senescence is a tumor-suppressive mechanism that permanently arrests cells at risk for malignant transformation. However, accumulating evidence shows that senescent cells can have deleterious effects on the tissue microenvironment. The most significant of these effects is the acquisition of

The dark side of protein kinase CK2 inhibition.

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Identifikohuni Regjistrohu

Casein kinase 2 (CK2) is a ubiquitous, highly pleiotropic and essential protein kinase whose abnormally high constitutive activity has been implicated in several human diseases. In the last decade, several ATP competitive inhibitors of CK2, characterized by an in vitro activity that ranges from

[Dark adaptation of patients with head and neck tumors].

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Identifikohuni Regjistrohu

20 patients with tumors of the head and neck region have a delayed dark adaption. The serum vitamin A levels in these patients are significantly diminished versus controls. Since disturbance of dark adaption does not occur before long during deficiency of vitamin A, it is assumed that the deficiency

The dark side of immunotherapy: challenges facing the new hope in cancer treatment.

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Identifikohuni Regjistrohu

Immune cells in pancreatic cancer: Joining the dark side.

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Identifikohuni Regjistrohu

Pancreatic tumors are rich in immune cell infiltrates that include CD4+ T-cell subsets encompassing both regulatory T cells and TH17 cells. Rather than protecting the organism by exerting an anticancer effect, these T-cell subsets promote tumor formation. Thus, re-activation of antitumor immunity

Cancer associated fibroblasts: the dark side of the coin.

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Identifikohuni Regjistrohu

Valid experimental evidence has recently shown that progression of malignant tumors does not depend exclusively on cell-autonomous properties of the cancer cells, but is also deeply influenced by tumor stroma reactivity and undergoes a strict microenvironmental control. Beside structural

[Vitamin A level and dark adaptation in patients with tumors].

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Identifikohuni Regjistrohu

Twenty patients with tumors of the head and neck region were found to have delayed dark adaptation. The serum vitamin A levels in these patients were significantly diminished in comparison with normal controls. Since disturbance of dark adaptation does not occur without prolonged vitamin A

Antimetastatic activity of the photodynamic agent hypericin in the dark.

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Identifikohuni Regjistrohu

A unique property of the photodynamic signal transduction inhibitor hypericin (HY) is high functionality in the dark, which has been shown to result in portfolio of anticancer activities both in vitro and in vivo. Here we show that treatment with HY significantly reduces growth rate of metastases in

Oncogene-dependent tumor suppression: using the dark side of the force for cancer therapy.

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Identifikohuni Regjistrohu

Cancers arise by an evolutionary process that involves the protracted acquisition by somatic cells of suites of interlocking mutations that uncouple proliferation, survival, migration, and damage responses from the mechanisms (selective pressures) that normally restrain or restrict them in time and

Noncoding RNA for personalized prostate cancer treatment: utilizing the 'dark matters' of the genome.

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Identifikohuni Regjistrohu

Prostate cancer is the most commonly diagnosed cancer in men in western countries, with significant health impact. Clinically, it is complicated with the lack of biomarkers and effective treatments for aggressive disease, particularly castration-resistant prostate cancer. Although we have gained

STAT5 Loss Awakens the Dark Force in Natural Killer Cells.

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Identifikohuni Regjistrohu

Natural killer cells (NK) are commonly considered to be potent antitumor effector cells. The study by Gotthardt and colleagues challenges this concept and reveals that STAT5-deficient/inhibited NK cells induce angiogenesis and promote tumor progression. These unexpected findings shed new light on

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