Relapsing Remitting Multiple Sclerosis

Modified Atkins diet

University of Virginia

Utilization of the Ketogenic Diet in Patient With Relapsing Remitting MS

The Effect of the Ketogenic Diet on Patients With Relapsing Remitting Multiple Sclerosis

Determine if patients are able to adhere to (number of days patient able to demonstrate ketosis) and tolerate a strict diet over an extended period of time as reported in urinary ketone analysis.

Determine the benefits, if any, of the ketogenic diet in RRMS subjects physically, emotionally, and clinically as reported in patient reported outcome surveys. Survey responses are evaluated on a scale of 0-10 with 0 being no affect and 10 being highly affected by the disease.

Assessment of height and weight to calculate subject BMI throughout the study. This will be compared with survey on physical activity to see if scores (no disease impact to high disease impact on activity) correspond with changes in BMI.

J. Nicholas Brenton, MD

Assistant Professor of Neurology and Pediatrics

Sodium propionate will be administered with a daily intake of 2 x 500 mg in form of capsules for 12 weeks.

Endstage Renal Disease

Sodium propionate is a non-toxic food additive, confirmed and licensed by the European Food Safety Authority (EFSA) sodium propionate E281. We are planning the oral application of 500 mg SP 2x per day. This dose is about 0.014 mg/kg of the body weight. Therefore, no risk of toxicity is expected in the patients.

Sodium Propionate

Effects of Short-chain Fatty Acids on Inflammatory and Metabolic Parameters in Maintenance Hemodialysis

Effects of Short-chain Fatty Acids, Here Sodium Propionate, a Metabolism Product of the Human Gut-microbiome, on Inflammatory and Metabolic Parameters in Patients on Maintenance Hemodialysis - a Pilot Study

endotoxin /lipopolysaccharide levels, high sensitivity C-reactive protein (hs-CRP), fibrinogen, interleukin 6 (IL-6), tumor necrosis factor α (TNF-α), IL-10, IL-2, INFγ, TGFβ, IL-4, IL-1β, IL-17a and white blood cell count.

glutathione peroxidase, malone dialdehyde

Determination of Homa Index (Homeostasis Model Assessment) by measurement fasting blood sugar and insulin level as well as hemoglobin HbA1c. IR appears to be as associated of metabolic disorders including lipid abnormalities, atherosclerotic cardiovascular disease and accelerated muscle protein degradation (Wang et al. 2006). IL is induced in particular by systemic inflammation.

Triglycerides, total cholesterol, high and low density cholesterol

Leptin, resistin, adiponectin and glucagon-like peptide -1.

p-cresyl sulfate, indoxyl sulfate and trimethylamine -N-oxide

Dr Biagio Di Iorio

Dr, Chief Nephrology Division

Azienda Sanitaria ASL Avellino 2

Healthy

Adm 100 U/kg sc 1 hour before completing exercise in protocol

encephalomyelitis/carbohydrate

Utilization of the Ketogenic Diet in Patient With Relapsing Remitting MS

Effects of Short-chain Fatty Acids on Inflammatory and Metabolic Parameters in Maintenance Hemodialysis

Can Erythropoietin Protect the Cerebral Blood Flow and Oxygenation During Simulated Dive?

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